基于等级碳纳米复合材料的电化学传感器,用于高灵敏度的西普罗夫洛克萨辛测定
Joanna Smajdor1, Beata Paczosa-Bator1, Robert Piech1
1Department of Analytical Chemistry and Biochemistry, Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Al. Mickiewicza, 30-059 Krakow, Poland.
Membranes
|July 28, 2023
概括
一种新的电压测量方法利用修改过的电极,对抗菌药物西普罗夫洛克萨 (CIP) 进行高度敏感的检测. 这一进步为复杂样品和药品提供了准确的CIP确定.
科学领域:
- 电化学 电化学 电化学
- 分析化学 分析化学
- 材料科学 材料科学 材料科学
背景情况:
- 齐普洛素 (CIP) 是一种重要的抗菌药物.
- 敏感和准确的CIP检测方法对于治疗药物监测和质量控制至关重要.
- 现有的方法可能面临复杂矩阵的挑战,或需要昂贵的设备.
研究的目的:
- 开发一种高度敏感的电压测量方法来检测西普洛素.
- 使用新型改造的电极来增强电化学传感.
- 在现实世界样本和制药配方中验证方法.
主要方法:
- 用层次电碳纳米纤维和NiCo纳米颗粒 (eCNF/CNT/NiCo-GCE) 修改的玻璃碳电极的制造.
- 修改过的电极的电化学特征.
- 在包括尿液,血,药品和抗生素盘在内的各种矩阵中对西普罗夫洛克萨进行伏特米分析.
主要成果:
- 对于CIP,eCNF/CNT/NiCo-GCE实现了6.0μmol L-1的低检测极限 (LOD).
- 记录了3.33μA μmol L-1的高测量灵敏度.
- 在复杂样本中获得了令人满意的恢复率 (94-104%).
- 电极在约4周内表现出极好的稳定性和良好的重复性 (RSD=2.4%).
结论:
- 采用eCNF/CNT/NiCo-GCE的拟议电压测量方法提供了一种高度敏感,稳定和可重复的方法来确定西普洛素.
- 该方法适用于在多样化和复杂矩阵中分析CIP.
- 简单且经济高效的电极制备使其成为实际应用的有前途的工具.
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