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双醇对内皮细胞和小鼠的血管新生活性和机制:结构选择性作用的证据

Liping Lu^1,2, Lilai Shen¹, Shixuan Cui¹

¹Key Laboratory of Environment Remediation and Ecological Health, Ministry of Education, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China.

Environmental science & technology

|July 28, 2023

概括

双暴露会影响血管健康. 双A (BPA) 和双S (BPS) 促进血管生长,而四双S (TBBPS) 通过破坏关键细胞通路来抑制其.

科学领域:

内分泌学在内分泌学.
血管生物学血管生物学
毒理学毒理学毒理学

背景情况:

流行病学研究将双暴露与血管疾病联系起来.
这些协会背后的确切机制尚不清楚.
双是内分泌干扰剂,可能对血管平衡有影响.

研究的目的:

研究具有不同结构的双醇的血管效应.
阐明二醇诱导血管生成的潜在分子机制.
评估环境相关双醇度对内皮细胞和小鼠模型的影响.

主要方法:

内皮细胞用双醇 (1nM到10μM) 进行治疗.
一个C57BL/6小鼠模型在5周内被食不同剂量的双 (每天0.002至20毫克/公斤) 5周.
分析了涉及酸丁3-激酶 (PI3K),雌激素受体 (ER) 和甲状腺受体 (TR) 相互作用的机制.

主要成果:

低剂量的双A (BPA) 和双S (BPS) (1nM) 显著增加了内皮管形成和微血管发芽.
高剂量的四博二S (TBBPS) (1μM) 显著抑制了管道长度和微血管发芽.
双甲和BPS增强了PI3K-ER相互作用,促进了亲血管效应.
博二S和博二A抑制PI3K-TR相互作用,导致抗血管效应.

结论:

双因其结构特征而表现出明显的血管新生活性.
对TR/ER-PI3K通路的干扰调解了双的不同血管性作用.
这些发现为内分泌干扰剂如何影响血管平衡提供了机械的见解.

关键词:

血管新生是因为血管新生.双二烯是一种双二烯.雌激素受体的受体是雌激素受体.酸氨基醇3 - 酶.蛋白质相互作用蛋白质相互作用甲状腺受体受体是什么

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