化疗与或没有选择性内部辐射疗法治疗肝脏内胆管癌:来自临床试验的数据
Julien Edeline1, John Bridgewater2, Boris Campillo-Gimenez3
1Department of Medical Oncology, Centre Eugène Marquis, Rennes, France and INSERM, Univ Rennes, COSS [(Chemistry Oncogenesis Stress Signaling)] - UMR_S 1242, F-35000 Rennes, France.
Hepatology (Baltimore, Md.)
|July 28, 2023
概括
选择性内部辐射疗法 (SIRT) 与化疗相结合,对仅肝脏的晚期肝内胆管癌 (iCCA) 显示出有前途. 在一项临床试验分析中,这种治疗改善了整体存活率和无进展存活率,与单独使用化疗相比.
科学领域:
- 肝胆道癌症 肝胆道癌症
- 干预性瘤学干预性瘤学
- 医学瘤学 医学瘤学
背景情况:
- 先进的,只有肝脏的肝脏内胆管癌 (iCCA) 提出了治疗挑战.
- 选择性内部辐射疗法 (SIRT) 在iCCA的非随机研究中显示出潜力.
研究的目的:
- 为了比较单独的第一线化疗与与SIRT结合的化疗在先进的,仅肝脏的iCCA中的结果.
- 用模拟目标试验范式分析潜在临床试验数据.
主要方法:
- 来自多项前性试验 (ABC-01,ABC-02,ABC-03,BINGO,AMEBICA,MISPHEC) 的个人患者数据被汇总在一起.
- 使用倾向分数的治疗权重反向概率 (IPTW) 将治疗组之间的偏差降到最低.
- 与接受SIRT加化疗的41名患者和仅接受化疗的73名患者进行了比较.
主要成果:
- SIRT加化疗显著改善了整体存活率 (中位数为21.7个月与15.9个月,HR=0.59,p=0.049).
- 随着联合治疗,无进展生存率也显著改善 (中位数为14.3个月与8.4个月,HR=0.52,p<0.001).
- 在所有灵敏度分析中,结果都很强.
结论:
- 与SIRT结合的化疗与单独的化疗相比,对于晚期的,仅肝脏的ICCA,可能会提供更好的结果.
- 需要进一步的随机对照试验来证实这些发现.
- 这项分析为SIRT在iCCA管理中的有效性提供了宝贵的见解.
相关概念视频
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
02:49Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K