免疫介导的炎症性疾病和心脏膜疾病的风险:孟德尔的随机化研究
Dihui Cai1, Zequn Zheng2,3, Jiale Hu1
1Department of Cardiology, Ningbo Institute of Innovation for Combined Medicine and Engineering, Lihuili Hospital Affiliated to Ningbo University, Ningbo University, Ningbo, Zhejiang, China.
Clinical rheumatology
|July 28, 2023
概括
像SLE,RA和IBD这样的免疫媒介性炎症性疾病 (IMID) 与膜性心脏病 (VHD) 有因果关系. 需要进一步的干预措施来降低这些疾病患者的VHD风险.
科学领域:
- 心血管医学 心血管医学
- 免疫学 免疫学 免疫学
- 遗传学 遗传学 是一个
背景情况:
- 观察性研究表明,免疫媒介性炎症性疾病 (IMID) 与膜心脏病 (VHD) 风险增加之间存在联系.
- IMIDs和VHD之间的因果关系尚不清楚.
- 门德尔随机化 (MR) 分析用于调查潜在的因果关系.
研究的目的:
- 评估基因预测的IMID与发展VHD的风险之间的因果关系.
- 为IMIDs和VHD之间的联系提供遗传证据.
主要方法:
- 进行了对两个样本的门德尔随机化 (MR) 分析.
- 使用了来自GWAS的暴露数据和来自FinnGen数据库的结果数据 (47,003例,182,971例对照).
- 应用了反变量加权 (IVW),MR-Egger和加权中位数方法,以及单变量和多变量MR.
主要成果:
- 遗传预测的系统性红斑狼 (SLE),类风湿性关节炎 (RA) 和炎症性肠病 (IBD) 被发现会增加VHD风险.
- 针对SLE,RA和IBD报告了特定的几率比率 (ORs) 和置信区间 (CI).
- 多变量MR表明,在调整吸烟,肥胖,冠状动脉疾病和高血压等因素后,IMIDs对VHD风险的影响减少了.
结论:
- 这项研究提供了第一个支持遗传预测IMID和VHD风险之间的因果关系的遗传证据.
- 这些发现表明,需要进一步探索积极的干预措施,以减轻在被诊断为SLE,RA和IBD的患者中VHD风险.
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