小体积管用于减少贫血和输血 (STRATUS):一个试点研究
Deborah M Siegal1,2,3,4,5, Emilie P Belley-Côté6,7, Shun Fu Lee6,7
1Department of Medicine, McMaster University, Hamilton, ON, Canada. dsiegal@toh.ca.
概括
对于重症监护室患者来说,小体积的采血管是可行的,可以减少血液流失而不会影响样品质量. 这支持进一步的试验,以评估输血减少.
科学领域:
- 临床医学 临床医学
- 实验室诊断 实验室诊断 实验室诊断
- 患者血液管理患者血液管理
背景情况:
- 为诊断测试采取血液样本有助于患者失去血液.
- 标准体积管是常见的,但小体积的替代品提供潜在的好处.
- 小体积管对重症监护室 (ICU) 输血需求的影响需要进行调查.
研究的目的:
- 评估在ICU环境中实施小容量的血液采集管的可行性.
- 评估小体积管在减少输血中的潜力,与标准体积管相比.
- 为了为更大的阶梯集群试验的设计提供信息.
主要方法:
- 在一个ICU中进行了一项前后设计的前性混合方法试点研究.
- 该研究包括一个为期六周的控制期 (标准体积管) 和一个为期六周的干预期 (小体积管).
- 通过成功实施,遵守,样本充分性,通过焦点小组接受用户,以及输血数据收集来评估可行性.
主要成果:
- 过渡到小体积管是成功的,100%的合规性和不充分的样品没有增加 (0.2%在两个组).
- 终端用户的接受度很高,在10个重点小组中没有发现障碍.
- 由于实验室检测,每天每名患者的估计血液损失显著减少,从11毫升 (标准) 降至6毫升 (小容量).
结论:
- 小体积的采血管可以在ICU中实现,用户接受度很高,没有明显的障碍.
- 使用小体积管不会影响样本适合用于诊断测试.
- 这些发现为确定的试验提供了强有力的基础,以确定小体积管是否减少了输血需求.
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