超重和肥胖儿童血清铜/比:一个横截面研究
Mu Du1, Mingfang Qiu1, Ye Qian1
1Department of Endocrinology, Children's Hospital of Capital Institute of Pediatrics, No. 2 Yabao Road, Chaoyang District, 100020, Beijing, People's Republic of China.
Biological trace element research
|July 28, 2023
概括
高血清铜/比 (CZR) 与儿童超重,肥胖和中心肥胖的几率增加有关. 这种关联在研究人口中的各种年龄组和性别中被观察到.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 营养生物化学 营养生物化学
- 公共卫生 营养 公共卫生 营养
背景情况:
- 儿童肥胖是一个日益严重的全球健康问题.
- 铜/比 (CZR) 是代谢障碍的一个潜在生物标志物.
- 了解与儿童肥胖相关的因素对于开发有效干预措施至关重要.
研究的目的:
- 调查血清铜/比 (CZR) 与儿童超重/肥胖之间的关联.
- 根据年龄和性别,探索这种关联中的潜在差异.
主要方法:
- 采用国家健康和营养检查调查 (NHANES) 数据的横截面研究.
- 包括8-18岁儿童的社会人口统计和临床数据.
- 进行了加权的单变量和多变量逻辑回归分析,以确定赔率比率 (OR) 和95%置信区间 (CI).
主要成果:
- 血清中CZR水平升高与超重 (OR=1.74),肥胖 (OR=5.26) 和中心肥胖 (OR=2.99) 的更高几率显著相关.
- 亚组分析显示,高血清CZR与12岁以上儿童和女性超重有关.
- 在12岁以上的儿童中,无论性别,都观察到肥胖和中心肥胖的几率增加.
结论:
- 血清铜/比升高是与儿童超重,肥胖和中心肥胖的几率增加相关的重要指标.
- 血清CZR和肥胖指标之间的关系在不同儿科年龄组和性别中持续存在.
- 血清CZR可以作为一种有价值的生物标志物,用于识别患肥胖和相关代谢并发症风险的儿童.
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