在中度至重度阻塞性睡眠呼吸暂停的肥胖个体中,与交感性过度活跃相关的动脉硬
Samanta Mattos1, Michelle R Cunha1, Márcia R S T Klein2
1Department of Clinical Medicine, State University of Rio de Janeiro (UERJ), Rio de Janeiro, Brazil.
概括
肥胖和中度至重度的阻塞性睡眠呼吸暂停 (OSA) 与增加动脉硬性和交感神经系统过度活动有关. 这项研究发现了中度至重度OSA的肥胖个体血管衰老加速的证据.
科学领域:
- 心血管生理学心血管生理学
- 睡眠医学 睡眠医学
- 肥胖问题研究研究
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一种慢性疾病,通常与肥胖有关.
- 增加的身体质量指数 (BMI) 和腰围与OSA严重程度有关.
研究的目的:
- 为了研究血管功能,中央血液动力学和自主神经系统调节.
- 在中度至重度OSA的肥胖个体中评估这些参数.
主要方法:
- 评估了76名肥胖个体 (BMI 30-40公斤/米2),年龄在40-70.
- 通过家庭睡眠测试 (WatchPAT) 评估心率变化,内皮功能 (流介导扩张),中心血液动力学 (振荡计,大脑动脉超声波) 和睡眠.
- 将参与者分为缺席的轻度 (AHI < 15) 和中度至重度 (MS,AHI ≥ 15) OSA组.
主要成果:
- 在MS OSA组表现出更高的LF/HF比率 (交感活动),脉冲波速度 (PWV,动脉硬),血管年龄和内心介质厚度.
- 呼吸暂停-呼吸暂停指数 (AHI) 与PWV和LF/HF比率有显著的相关性.
- 在多发性硬化组中,PWV与心率变化 (SD2/SD1) 相相关,流量介导扩张与中央静脉压相关.
结论:
- 在肥胖个体中,中度至重度的OSA与同情性多动症有关.
- 结果表明血管衰老加速,其特征是动脉硬和亚临床动脉样硬化.
- 这些结果凸显了OSA在肥胖人口中的显著心血管影响.
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