引入常规益生菌补充剂后对非常早产婴儿的新生儿结局
David B Healy1,2,3, Benjamin Campbell-Green2, Vicki Livingstone2,3
1APC Microbiome Ireland, UCC, Cork, Ireland.
Acta paediatrica (Oslo, Norway : 1992)
|July 28, 2023
概括
常规服用Bifidobacterium bifidum和Lactobacillus acidophilus的益生菌补充剂显著降低了非常早产婴儿中严重死性肠球炎 (NEC) 和/或死亡的综合结果. 这一发现支持在新生儿重症监护中使用益生菌.
科学领域:
- 新生儿医学 新生儿医学
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 死性肠球炎 (NEC) 和死亡是非常早产婴儿的重大担忧.
- 益生菌补充作为改善新生儿结果的策略正在被探索.
- 双菌 (Bifidobacterium bifidum) 和乳酸菌 (Lactobacillus acidophilus) 是常用的益生菌菌株.
研究的目的:
- 评估常规益生菌补充剂 (Bifidobacterium bifidum和Lactobacillus acidophilus) 对死亡和/或严重NEC的综合结果的影响.
- 为了比较在科克大学妇产医院引入益生菌之前和之后的非常早产婴儿的结果.
主要方法:
- 婴儿<32周怀孕和<1500g生存超过72小时的回顾性研究.
- 分析了两个6年的时代:前益生菌 (2008-2013) 和益生菌 (2015-2020).
- 主要结局:72小时后死亡或NEC钟声阶段2a或更高.
主要成果:
- 包括744名婴儿 (391名在第1个时代,353名在第2个时代).
- 主要结局发生在67名婴儿身上 (37名在第1个时代,30名在第2个时代).
- 在调整后,益生菌使用与复合结果显著降低有关 (OR:0.53 [0.29至0.97],p=0.038).
结论:
- 常规服用Bifidobacterium bifidum和Lactobacillus acidophilus益生菌与严重NEC和/或死亡的减少有关.
- 这些发现表明,这些益生菌在非常早产的婴儿身上具有保护作用.
- 调整后的分析表明,独立于妊娠年龄组,有显著的益处.
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