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在多壁碳纳米管上吸附的二甲基甲酸盐在Balb/C小鼠中引起胎儿发育毒性

Yujie Qin¹, Suli He¹, Haiyan Peng¹

¹Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan 430079, China.

|July 28, 2023

概括

被多壁碳纳米管 (MWCNTs) 携带的迪布甲酸盐 (DBP) 暴露的小鼠经历了延迟的DBP降解,增加了雌激素效应,以及更高的胎儿死亡率. 这种组合显著影响了生殖健康和发育.

科学领域:

环境毒理学环境毒理学
纳米材料的安全性
生殖毒理学生殖毒理学

背景情况:

酸盐,如迪布酸 (DBP),是具有已知的不良影响的内分泌干扰化学物质.
像多壁碳纳米管 (MWCNTs) 这样的纳米材料越来越多地被使用,这引发了人们对它们与环境污染物的相互作用的担忧.
作为DBP的携带者,MWCNT对生殖健康的综合影响尚不清楚.

研究的目的:

为了调查MWCNT是否在体内延迟DBP降解.
确定MWCNT是否增强了DBP的雌激素类干扰.
评估MWCNT-DBP组合对小鼠胎儿发育和生殖参数的影响.

主要方法:

怀孕的Balb/C小鼠通过尾脉注射暴露于MWCNTs,DBP或其组合.
对雌性和雄性后代进行了毒理学研究.
进行了对性激素合成途径的组织病理学分析 (H&E染色) 和基因表达分析.

主要成果:

与单个暴露相比,MWCNT-DBP组合导致更高的胎儿死亡率.
在组合组中观察到延迟的雌性周期,阻断卵细胞发育,减少精子生成细胞和降低精子质量.
结合治疗组中,与生殖腺性激素合成相关的基因表达显著增加 (p < 0.01).

结论:

MWCNTs延迟了DBP的降解,延长了其暴露时间,并增强了其类似雌激素的效果.
联合暴露会干扰胎儿发育和生殖健康,导致胎儿死亡率增加.
这项研究强调了使用MWCNT作为内分泌干扰化学品的载体的潜在风险.

关键词:

复合暴露复合暴露复合暴露双乙烯甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸二甲酸鼠标鼠标鼠标鼠标多壁碳纳米管多壁碳纳米管生殖性毒性生殖性毒性

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