性病症严重性的性别差异
Supabhorn Yimthiang1, David A Vesey2,3, Glenda C Gobe2,4,5
1Occupational Health and Safety, School of Public Health, Walailak University, Nakhon Si Thammarat 80160, Thailand.
Toxics
|July 28, 2023
概括
慢性 (Cd) 暴露会导致损伤,包括管状病变和估计膜过率 (eGFR) 降低. 女性对Cd诱导的毒性敏感性更高,患这些疾病的风险增加.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 慢性 (Cd) 暴露与管道病变有关,其特征是β2-微球蛋白 (β2M) 排泄量升高.
- 新出现的证据表明,Cd也可能导致缩,导致估计膜过率 (eGFR) 降低.
研究的目的:
- 研究污染和非污染地区居民的暴露,管道病变和降低的EGFR之间的关系.
- 检查吸烟,糖尿病和高血压等混因素对这些引起的病态的影响.
- 为了确定性别特异性对腎毒性的敏感性.
主要方法:
- 一项涉及泰国448名居民的横截面研究.
- 测量分泌 (ECd) 和β2-微球蛋白分泌 (Eβ2M),正常化为肌素清除 (Ccr).
- 统计分析以调整混因素并评估剂量反应关系和关联.
主要成果:
- 增加的体负担 (ECd/Ccr) 与每10倍增加的管道病变 (1.9倍) 的更高的患病概率比率和降低的eGFR (3.2倍) 相关.
- 在女性中观察到Eβ2M/Ccr和ECd/Ccr之间的剂量效应关系.
- 严重的管道病变与女性 (16.5毫升/分钟/1.73米2) 和男性 (12.3毫升/分钟/1.73米2) 的平均EGFR显著较低有关.
结论:
- 暴露显著增加了管道病变和降低EGFR的风险,独立于其他风险因素.
- 妇女对的毒性作用的敏感性增加.
- 升高的β2M分泌主要是由于损害的管状再吸收和诱导的脏损失.
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