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尼泊尔人群中HIV感染患者的HCV共感染及其基因型分布

Uday Kant Sah¹, Anil Kumar Sah², Mehraj Ansari³

¹Department of Biochemistry, Singhania University, Pacheri Bari, Rajasthan 333515, India.

Tropical medicine and infectious disease

|July 28, 2023

概括

在尼泊尔,患有人类免疫缺陷病毒 (HIV) 的人群中,C型肝炎病毒 (HCV) 联合感染很常见,基因型3是最常见的. 这一发现有助于管理HCV共感染,以改善PLHIV患者的生活质量.

科学领域:

* 传染病传染病
* 病毒学病毒学
* * 公共卫生公共卫生

背景情况:

* 携带人类免疫缺陷病毒 (HIV) 的人群中,C型肝炎病毒 (HCV) 联合感染的流行率和基因型分布在全球范围内有所不同.
*了解特定人群中的这些模式对于有效管理至关重要.
*尼泊尔需要有关HCV/HIV联合感染的局部数据.

研究的目的:

*确定尼泊尔艾滋病毒感染者 (PLHIV) 中HCV的流行率和基因型分布.
* 分析HCV病毒载量模式在这个同时感染的人群.
*为管理HCV/HIV联合感染的策略提供信息.

主要方法:

* 在尼泊尔加德满都进行了一项涉及203名艾滋病病毒阳性患者的横截面研究.
*HCV病毒载量和基因型使用标准Q-PCR协议对血RNA进行量化.
*关于艾滋病毒感染持续时间,年龄,性别和ART治疗方案的数据被收集为共变量.

主要成果:

* 在PLHIV患者中,HCV同时感染的患病率为56.6% (203分之115).
*男性性别与HCV联合感染的更高患病率有关.
* 基因型3 (特别是3a) 是最常见的HCV变体 (61.1%),病毒载量通常在34~3000IU/mL之间.

结论:

* 在研究的尼泊尔PLHIV人群中,HCV共感染非常普遍.
*3型基因型是这种共感染群体中占主导地位的HCV变体.
*研究结果支持针对PLHIV患者的HCV联合感染的向管理策略,以改善健康结果.

关键词:

在HCV的基因型.艾滋病毒病毒载量 (HCV)艾滋病病毒艾滋病病毒艾滋病病毒在 PLHIV HIV 中.

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