三维模型和微生理系统在评估真菌毒素毒性的日益重要
Veronica Zingales1,2,3, Maria Rosaria Esposito2,3, Noemi Torriero2,3
1Laboratory of Toxicology, Faculty of Pharmacy, University of Valencia, Av. Vicent Andrés Estellés s/n, 46100 Valencia, Spain.
Toxins
|July 28, 2023
概括
本综述探讨了先进的3D细胞培养模型,包括球形培养物和器官芯片系统,作为传统毒理学测试的优越替代方案. 这些方法为改善风险评估提供了更准确的体内总结.
科学领域:
- 毒理学 毒理学 毒理学
- 细胞生物学 细胞生物学
- 生物技术是生物技术.
背景情况:
- 传统的毒理学依赖于二维细胞培养和动物模型,它们在模拟体内微环境方面存在局限性.
- 越来越需要替代模型来更好地概述人类组织和器官的复杂架构.
研究的目的:
- 审查当前的3D细胞培养技术,特别是球形培养和芯片器官系统.
- 讨论建立这些先进模型的概念和技术考虑因素.
- 评估它们在毒理学功能测定和真菌毒素评估中的应用.
主要方法:
- 关于球形培养技术的讨论.
- 对芯片器官技术的审查.
- 在这些3D系统中分析毒理学功能测试.
主要成果:
- 与2D模型相比,3D细胞培养提供了更好的体内条件回顾.
- 球状培养物和器官芯片系统在毒理学研究中具有明显的优势和局限性.
- 特别关注3D模型对菌根毒素毒性评估的有用性.
结论:
- 3D细胞培养模型对提高毒理风险评估的准确性和稳定性显示出希望.
- 标准化和验证仍然是3D文化技术进一步发展的关键领域.
- 这些替代方法可以显著改善监管政策的安全范围定义.
相关概念视频
01:26Pharmacokinetic Models: Comparison and Selection Criterion
109
Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
109
01:20Pharmacokinetic Models: Overview
790
Pharmacokinetic models utilize mathematical analysis to achieve a detailed quantitative understanding of a drug's life cycle within the body. They are instrumental in simulating a drug's pharmacokinetic parameters, predicting drug concentrations over time, optimizing dosage regimens, linking concentrations with pharmacologic activity, and estimating potential toxicity.
There are three primary types of models: empirical, compartment, and physiological. Empirical models, with minimal...
There are three primary types of models: empirical, compartment, and physiological. Empirical models, with minimal...
790