双A和双S在血液分析仪中的双
Zahin Haq1, Xin Wang1, Qiuqiong Cheng2
1Renal Research Institute, New York, NY 10065, USA.
Toxins
|July 28, 2023
概括
在血液透析器中检测到双A (BPA) 和双S (BPS). 目前的水平表明患者安全,但随着更多的毒性数据的可用性,未来可能需要重新评估暴露极限.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 材料科学 材料科学 材料科学
背景情况:
- 双A (BPA) 用于血液透析器制造,引发了健康问题.
- 对BPA的监管审查正在增加,导致使用像Bisphenol S (BPS) 这样的替代品.
- 了解血液透析中患者暴露于BPA和BPS的风险至关重要.
研究的目的:
- 量化商用血液透析器中的双A (BPA) 和双S (BPS) 含量.
- 评估血液透析期间与BPA和BPS暴露相关的潜在患者风险.
主要方法:
- 使用向液体染色体质谱学分析八个血液透析器的可提取物和可浸出物.
- 使用稳定同位素标记的内部标准和标准加法进行量化.
- 在含有这些化合物的材料中检测BPA和BPS,但具体除外.
主要成果:
- 在大多数测试过的透析器中检测到BPA (0.4332.82μg/设备) 和BPS (0.022.51μg/设备).
- 在FX CorAL 120透析器,血统控制和基于纤维素的膜中,没有可检测到的BPA或BPS.
- 计算的安全边际表明,在当前的暴露水平下,不良影响不太可能发生.
结论:
- 血液透析器含有可测量的BPA和BPS,有些产品没有显示可检测量的量.
- 目前在血液透析期间的BPA和BPS暴露水平似乎是安全的,基于确定的可容忍摄入量.
- 由于新出现的毒性数据,建议对安全限值进行持续监测和潜在的重新评估.
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