在急性髓性白血病 (AML) 患者中长非编码RNAAB073614和FER1L4的表达和变化值

在急性髓性白血病 (AML) 患者中长非编码RNAAB073614和FER1L4的表达和变化值

相关实验视频

Updated: Jul 21, 2025

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells

09:16

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells

Published on: September 1, 2019

7.6K

Ali Ganji¹, Mahmood Khosravi², Ghasem Mosayebi¹

¹Department of Immunology and Microbiology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.

Asian Pacific journal of cancer prevention : APJCP

|July 28, 2023

概括

长非编码RNAsAB073614和FER1L4在急性髓性白血病 (AML) 中表达的变化. 上调的AB073614和下调的FER1L4可以作为AML的诊断生物标志物.

科学领域:

分子生物学分子生物学
在瘤学瘤学.
生物标志物发现发现

背景情况:

长非编码RNAs (lncRNAs) AB073614和FER1L4放松调节与各种癌症有关.
它们在急性髓性白血病 (AML) 中的特定作用和表达模式尚不清楚.
PI3K信号通路参与了AML的发病过程,这表明与这些lncRNA的潜在联系.

研究的目的:

在AML患者中研究lncRNAs AB073614和FER1L4的表达水平.
确定这些lncRNAs在AML中的临床意义和诊断价值.
通过PI3K途径探索涉及这些lncRNAs在AML发展中的潜在机制.

主要方法:

量化逆转录-聚合酶连锁反应 (qRT-PCR) 用于测量30名AML患者和12名健康对照的lncRNA表达.
统计分析将ncRNA表达与临床病理特征相关联.
进行了接收器操作特征 (ROC) 曲线分析,以评估诊断准确性.

主要成果:

与对照组相比,AB073614在AML患者中显著上调 (p < 0.05).
在AML样本中,AB073614表达与FER1L4表达相反相关 (p <0.05).
观察到高诊断准确度,对AB073614的灵敏度为96.7%,对FER1L4的灵敏度为100%,对两者的特异性为100%.

结论:

AB073614和FER1L4显示出作为AML的预后生物标志物的潜力.
这些lncRNAs的放松调节可能会通过不平衡的PI3K/PTEN信号传递促进AML的发病.
这些lncRNA及其相关途径组件代表了AML的潜在治疗点.

关键词:

AB07361414 AB07361414 AB07361414 AB07361414 AB07361414 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB073614 AB0727 AB073614 您的姓名是什么意思?您的姓名是什么意思?在AML,AML就是AML.在FER1L4L4中使用.在PI3K/Akt.在这里,我们可以看到PTEN.

更多相关视频

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

07:39

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

174

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

09:01

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

14.0K

相关概念视频

01:32

RNA Splicing

56.5K

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...

56.5K

Differentiation of Common Myeloid Progenitor Cells

01:15

Differentiation of Common Myeloid Progenitor Cells

3.2K

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...