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使用非线性技术的机器学习模型改善了在接受血液透析的个体中休息能量消耗的预测
Alainn Bailey1, Mohamed Eltawil2, Suril Gohel2
1Department of Clinical and Preventive Nutrition Sciences, School of Health Professions, Rutgers University, New Brunswick, NJ, USA.
Annals of medicine
|July 28, 2023
概括
机器学习 (ML) 显著提高了透析患者估计休息能量消耗 (eREE) 的计算精度,特别是那些高风险的蛋白质能量浪费 (PEW) 患者. 这一进步为这个弱势群体提供了更好的治疗策略.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 营养科学 营养科学
- 生物医学工程 生物医学工程
背景情况:
- 在美国,大约有70万个人患有需要透析的慢性病.
- 蛋白质能量浪费 (PEW) 显著影响透析患者的生存率 (50%在三年内),发生在所有身体质量指数 (BMI) 水平.
- 目前用于评估透析患者PEW和能量消耗的方法不准确,阻碍有效治疗.
研究的目的:
- 将机器学习 (ML) 建模技术应用于透析患者的临床数据库.
- 与传统方法相比,评估ML算法在计算估计的静止能量消耗 (eREE) 中的精度.
- 提高eREE计算的准确性,以更好地管理透析患者的PEW.
主要方法:
- 对罗格斯大学营养和脏数据库进行了二次分析.
- 开发和优化了11个ML模型,并根据测量REE的最低根平均平方误差 (RMSE) 选择了最好的3个.
- 使用布兰德-阿尔特曼图表来比较精度,用MHDE方程对ML模型进行评估.
主要成果:
- 最好的ML模型 (SVR,线性回归,弹性网) 的RMSEs分别为103.6,119.0和121.1千卡.
- 支持向量回归 (SVR) 模型显示了最高的精度,其中91.2%的值处于可接受的范围内,而MHDE则为47.1%.
- 非线性ML模型在极端的BMI范围内提供了精确的eREE估计.
结论:
- 机器学习提高了对透析患者的eREE计算的精度,包括那些对PEW最脆弱的人.
- 这些ML模型提供了更准确的能源支出评估,这对于管理PEW至关重要.
- 进一步开发临床应用的ML模型是改善患者治疗结果的优先事项.
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