通过原卡特丘酸保护对代谢相关的脂肪肝疾病
Jijun Tan1, Ruizhi Hu1, Jiatai Gong1
1Hunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients, College of Animal Science and Technology, Hunan Agricultural University, Changsha, China.
Gut microbes
|July 28, 2023
概括
饮食中的原卡特丘酸 (PCA) 通过减少有害的肠道细菌,特别是肠球菌,并恢复参与脂质代谢和胰岛素信号的关键基因表达,从而预防代谢相关的脂肪肝疾病 (MAFLD).
科学领域:
- 微生物学 微生物学
- 肝病学 肝病学是一种肝病学.
- 营养科学 营养科学
背景情况:
- 肠道微生物群与饮食的相互作用在代谢相关脂肪肝病 (MAFLD) 病原发生过程中至关重要.
- 饮食中的多醇显示出缓解MAFLD的潜力,但机制尚不清楚.
- 果酸 (PCA) 已成为MAFLD干预的有前途的候选人.
研究的目的:
- 调查PCA对高脂肪饮食诱导的小鼠MAFLD的保护作用.
- 阐明涉及PCA的肠道微生物群和脂质代谢调节的潜在机制.
主要方法:
- 通过高脂肪饮食诱导的MAFLD小鼠模型.
- 便微生物群移植 (FMT) 实验.
- 脂管学和转录学分析.
- 评估肝酶,炎症性细胞因子和肠道微生物群的组成.
主要成果:
- 饮食PCA显著降低了肝脏脂肪沉积,肝脏酶 (AST,ALT) 和炎症标志物.
- 通过PCA调节肠道微生物群,通过减少*Enterococcus*的丰度来降低Firmicutes/Bacteroidetes的比率.
- *Enterococcus faecalis*的使用加剧了MAFLD,而PCA通过恢复*CPT1α*和*Fgf1*表达来逆转这些影响.
结论:
- 高比例的*Enterococcus faecalis*加速了MAFLD的进展.
- 通过抑制*Enterococcus faecalis*和恢复关键基因表达,PCA可以改善MAFLD.
- 饮食PCA代表了MAFLD管理的潜在治疗策略.
更多相关视频
07:03Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
Published on: July 19, 2024
958
08:35A Model of Experimental Steatosis In Vitro: Hepatocyte Cell Culture in Lipid Overload-Conditioned Medium
Published on: May 18, 2021
6.4K
相关概念视频
01:28Overview of Fatty Acid Metabolism
30.8K
Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
30.8K
01:29Cholesterol: Significance and Regulation
588
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
588
01:24Overview of Lipid Metabolism
1.8K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.8K
01:26Atherosclerosis III: Management
12
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
12
01:24Chronic Pancreatitis I: Introduction
116
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
116
01:29Chronic Pancreatitis II: Collaborative Care
113
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
113