自免疫性肝脏疾病和糖尿病
Anne-Sofie H Jensen1,2, Henriette Ytting2,3,4, Marie Winther-Sørensen1
1Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen.
European journal of gastroenterology & hepatology
|July 28, 2023
概括
患有自身免疫性肝病的患者可能面临患糖尿病的风险增加. 对这些人来说,监测葡萄糖水平和糖尿病至关重要,特别是那些患有晚期肝硬化的人.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
背景情况:
- 自身免疫性肝病 (AILD),如自身免疫性肝炎,原发性胆道胆炎和原发性硬化胆炎是影响肝功能的慢性疾病.
- 肝脏对于葡萄糖平衡至关重要,其他慢性肝脏疾病与葡萄糖乱和糖尿病有关.
- 现有的关于AILD患者葡萄糖代谢的数据有限,但表明1型和2型糖尿病的潜在风险增加.
研究的目的:
- 突出自身免疫性肝病与葡萄糖乱之间的潜在关联.
- 强调需要提高对AILD患者糖尿病的认识和监测.
- 讨论这种人群中糖尿病潜在的潜在机制和管理考虑.
主要方法:
- 关于自身免疫性肝病中葡萄糖干扰现有文献的综述.
- 分析潜在的促成因素,包括遗传倾向,同时存在的疾病 (NAFLD,肝硬化) 和治疗效应 (类固醇).
- 讨论目前的糖尿病检测和管理指南,特别考虑晚期肝硬化.
主要成果:
- 有证据表明,在患有自身免疫性肝脏疾病的患者中,可能会增加1型和2型糖尿病的风险.
- 潜在的机制尚不清楚,但可能涉及遗传因素,并发性肝病或类固醇治疗.
- 在晚期肝硬化中,HbA1c可能不可靠;通常建议胰岛素治疗.
结论:
- 自身免疫性肝脏疾病可能会增加患糖尿病的风险,需要提高临床警.
- 标准糖尿病指南适用,但对于晚期肝硬化患者需要进行调整.
- 进一步的研究对于阐明糖尿病风险和优化自身免疫性肝病的管理至关重要.
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