环状岛标志是否是帕金森病早期痴呆转化标志?
Seok Jong Chung1,2,3, Su Hong Kim4,5,6, Chan Wook Park1,7
1Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea.
European journal of neurology
|July 28, 2023
概括
逆带带状岛屿标志 (CIS) 比率,而不是高CIS比率,与帕金森病 (PD) 患者早期痴呆转化有关. 这一发现有助于预测PD患者的认知能力下降.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 痴呆症研究 痴呆症研究
背景情况:
- 帕金森病 (PD) 是一种神经退行性疾病.
- 早期识别痴呆症转化风险到PD对于及时干预至关重要.
- 大脑 perfusion 扫描中的带状环岛标志 (CIS) 比率是一个潜在的生物标志物.
研究的目的:
- 确定带带状岛屿标志 (CIS) 比率是否与帕金森病 (PD) 早期痴呆转化有关.
- 调查高CIS比率与逆CIS比率对PD患者痴呆症发展的预测值.
主要方法:
- 226名新诊断的PD患者和48名对照患者接受了18F-FP-CIT PET扫描.
- 患PD的患者被分为PD-CIS (高比率),PD-iCIS (逆比率) 和PD-nCIS (正常比率) 组.
- 痴呆症转化风险在5年期间在各组之间进行了比较.
主要成果:
- 在PD组之间没有观察到人口统计或认知的显著基线差异.
- PD-CIS组显示出更高的运动分数和减少多巴胺载体的可用性.
- 与PD-nCIS相比,PD-iCIS组表现出较小的海马体积和更高的痴呆转化风险.
- PD-CIS组的痴呆症转化风险与PD-iCIS或PD-nCIS组没有显著差异.
结论:
- 反向CIS比率,而不是高CIS比率,与帕金森病的早期痴呆转化有关.
- 在PD-iCIS群体中,患痴呆症的风险较高.
- CIS比率可以作为PD认知衰退的预测生物标志物.
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