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细胞内生存的真菌机制:我们可以从细菌病原体中学到什么?

Peter V Stuckey¹, Felipe H Santiago-Tirado^1,2,3

¹Department of Biological Sciences, University of Notre Dame , Notre Dame, Indiana, USA.

Infection and immunity

|July 28, 2023

概括

侵袭性真菌感染是全球日益严重的健康威胁,每年造成数百万人的死亡. 这篇评论探讨了像Candida albicans这样的真菌如何逃避免疫细胞,为新疗法提供了洞察力.

科学领域:

医学真菌学医学真菌学
免疫学免疫学免疫学
病原体生物学病原体生物学

背景情况:

真菌感染对全球健康造成重大负担,死亡率高,特别是在免疫力低下的人群中.
越来越多的抗真菌药物耐药性和有限的治疗选择加剧了控制侵入性真菌病的挑战.
病原体已经发展出复杂的机制,在宿主免疫细胞内生存,逃避免疫反应.

研究的目的:

审查当前关于真菌病原体逃避和宿主免疫细胞内持久性的知识.
要突出主要真菌病原体如Cryptococcus neoformans,Candida albicans和Aspergillus fumigatus所使用的策略.
为了指导未来的研究,在真菌和细菌细胞内病变之间进行并行.

主要方法:

关于了解真菌与宿主免疫细胞相互作用的近期进展的文献综述.
分析真菌规避免疫系统的策略,包括形态变化和代谢适应.
在真菌和细菌物种之间对致病机制的比较分析.

主要成果:

病原体利用各种策略在细胞内生存,如改变形态和抵消巨细胞的防御.
与细菌病变发生相比,真菌细胞内生存的机制不太了解.
菌类和细菌在逃避宿主免疫力的策略之间存在相似之处.

结论:

了解真菌免疫逃避机制对于开发有效的治疗方法至关重要.
从细菌病变发生的洞察力可以为研究真菌感染提供信息.
对真菌细胞内生存策略的进一步研究有望改善对破坏性真菌疾病的治疗方法.

关键词:

亚斯伯吉拉斯烟虫 (Aspergillus fumigatus) 是一种有毒的植物.在Candida albicans中使用.这是Cryptococcus neoformans的新型菌.血清质体中的血清体.这些是真菌效应器.菌类病原体的真菌病原体菌类与宿主之间的相互作用

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