在肌病中终止皮质类固醇注射? 哈斯塔拉维斯塔,宝贝的宝贝
The Journal of orthopaedic and sports physical therapy
|July 28, 2023
概括
由于复发和破裂的风险,不建议在阿基勒斯肌病或足底筋病症中注射皮质类固醇. 有证据表明,与这些疾病的其他治疗方法相比,它们没有提供长期益处.
科学领域:
- 整形外科 整形外科 整形外科
- 运动医学 运动医学
- 物理疗法物理治疗
背景情况:
- 阿基里斯肌病和足底筋病是常见的肌肉骨疾病.
- 局部皮质类固醇注射已被用作治疗选择,有时与运动治疗相结合.
研究的目的:
- 批判性地评估最近关于肌病的皮质类固醇注射的证据.
- 提供临床推理,以指导医疗保健专业人员在向患者提供皮质类固醇注射方面的建议.
主要方法:
- 审查最近的随机对照试验.
- 对肌病的皮质类固醇注射的证据的系统审查.
- 临床推理和专家意见.
主要成果:
- 最近的试验显示,皮质类固醇注射与运动相结合的短期结果很有希望.
- 系统性审查表明,对于肌病,皮质类固醇注射在最初的几周之后并不有效.
- 与替代治疗相比,皮质类固醇注射的长期结果更糟糕.
结论:
- 皮质类固醇注射不推用于治疗阿基里斯肌病和脚部筋膜病.
- 更高的复发率和肌破裂的风险超过了潜在的好处.
- 临床医生应建议不要为这些疾病注射皮质类固醇,优先考虑其他基于证据的治疗方法.
更多相关视频
相关概念视频
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
153
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
153
01:20Desensitization and Tachyphylaxis
1.8K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
1.8K
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
300
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
300
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
195
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
195