不对称的的脱化,通过基激活的合作性黄金催化
Yongliang Zhang1, Ke Zhao1, Xinyi Li1
1Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA, 93106, USA.
Angewandte Chemie (International ed. in English)
|July 28, 2023
概括
一种新的黄金 (I) 催化反应使得使用奇拉连接体的醇能够进行抗选择性脱氧化. 这种多功能方法有效地合成复杂的螺旋环化合物,具有高产量和抗选择性.
科学领域:
- 有机化学 有机化学
- 催化剂是一种催化剂.
- 不对称的合成方法
背景情况:
- Dearomatization反应对于构建复杂的分子架构至关重要.
- 开发用于 dearomatization 的 enantioselective 方法仍然是有机合成的一个重大挑战.
研究的目的:
- 开发一种高效且具有抗选择性的黄金 (I) 催化醇的脱化.
- 探索这种新型催化系统的范围和局限性.
主要方法:
- 使用一种性双功能素连接体用于黄金 (I) 催化.
- 研究金属合金合作,以提高反应性和选择性.
- 使用各种替代的和基底.
主要成果:
- 实现了的高效和高度酶选择性 dearomatization.
- 证明了广泛的基质范围,耐受多样化的功能组和固体体积.
- 在高产率 (高达99%) 和酶选择性 (高达99%) 和酶选择性 (高达99% ee) 中成功合成了螺旋环基氨酸-pyrrol-2-ones, -butenolides 和 -cyclopentenones.
结论:
- 开发的金 ((I) 催化系统提供了一条强大而通用的途径,以获得合体丰富的螺旋环化合物.
- 金属-合物合作是观察到的高效率和反选择性的关键.
- 这种方法为复杂有机分子的合成提供了显著的潜力.
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