LP(a):结构,遗传学,相关心血管风险和新兴治疗方法
Erfan Tasdighi1,2, Rishav Adhikari3, Omar Almaadawy4
1Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA;
Annual review of pharmacology and toxicology
|July 28, 2023
概括
升高的脂蛋白 (Lp) 是一种遗传性心血管疾病风险因素,对当前的治疗没有反应. 基于RNA的新型疗法在降低Lp(a) 方面表现有前途,并可能个性化未来的心血管风险降低策略.
科学领域:
- 心血管医学 心血管医学
- 遗传学 遗传学 是一个
- 药理学 药理学是指药理学的学科.
背景情况:
- 脂蛋白 (Lp) 是心血管疾病 (CVD) 的重要,基因决定的风险因素,涉及炎症,动脉动脉生成和血栓形成.
- 升高的Lp (a) 影响全球大约20%的人口.
- 目前的失脂症管理策略在很大程度上无效降低Lp (a) 水平.
研究的目的:
- 审查脂蛋白 (Lp) 作为心血管疾病风险因素的作用.
- 讨论当前治疗升高Lp的局限性.
- 突出新兴基于RNA的治疗方法对Lp (a) 减少的潜力.
主要方法:
- 对Lp (a) 和心血管疾病的当前文献的综述.
- 对正在进行的RNA疗法III期临床试验 (Lp(a) HORIZON,OCEAN(a)) 的分析.
- 讨论针对心血管残留风险的个性化医疗方法.
主要成果:
- 新兴的基于RNA的疗法,包括反感性寡核酸 (pelacarsen) 和小干扰RNA (olpasiran),显示出显著的Lp (a) 减少.
- 目前正在进行的关键试验正在评估这些药物在二次心血管疾病预防中的有效性.
结论:
- 基于RNA的新型疗法代表了针对升高的Lp (a) 和降低心血管残留风险的有希望的策略.
- 未来的心血管保健可能涉及个性化治疗方法,包括向降低Lp (a) 与LDL-C和甘油三一起.
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