二次性偏甲状腺症和移植后的三级性偏甲状腺症的治疗方法
Caitlin E Egan1, Murtaza Qazi1, Joyce Lee1
1Department of Surgery, Weill Cornell Medicine, New York, New York.
The Journal of surgical research
|July 28, 2023
概括
与cinacalcet相比,移植前的甲状腺切除术可以改善二次性甲状腺功能障碍症 (sHPT) 的控制,并减少三级性甲状腺功能障碍症 (tHPT) 的发展. 这导致了移植后更好的PTH管理.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 移植 移植 移植 移植
背景情况:
- 二次性甲状腺功能障碍症 (sHPT) 在透析患者中很常见,并且可以在移植后发展为三级性甲状腺功能障碍症 (tHPT).
- 移植前的sHPT管理对于优化移植后的结果至关重要.
研究的目的:
- 评估sHPT移植前治疗对移植结果的影响.
- 为了比较甲状腺切除术与cinacalcet在移植前的sHPT管理.
主要方法:
- 对接受脏移植的接受者进行了回顾性审查,这些接受者接受了sHPT治疗,包括副甲状腺切除术或cinacalcet.
- 移植前和移植后的生化参数,临床结果和全移植功能的比较.
主要成果:
- 副甲状腺切除术与移植时更高的受控sHPT率 (88.9%vs47.8%) 和较低的tHPT发育率 (5.9%vs42.1%) 相关.
- 经过副甲状腺切除术治疗的患者在移植后的PTH水平显著降低 (60.7对170.0智商),并且移植后需要减少cinacalcet (11.1%对52.2%).
- 在两组治疗中,全移植功能和存活率是可比的.
结论:
- 对sHPT进行移植前甲状腺切除术与更好地控制PTH水平以及移植后减少tHPT的发生率有关.
- 需要进一步的大规模研究来证实这些长期结果.
关键词:
在中国,石是石.腎臟移植 腎臟移植副甲状腺切除术 (parathyroidectomy) 是一种切除甲状腺的方法.二次性副甲状腺功能障碍症是什么三级甲状腺功能障碍症 (Tertiary hyperparathyroidism) 是一种三级甲状腺功能障碍症.更多相关视频
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