普罗波与雷米马佐拉姆在全身麻醉后的出现形状上的比较:一项随机临床试验
Eun Jung Oh1, Yoon Joo Chung2, Jong-Hwan Lee2
1Department of Anesthesiology and Pain Medicine, Chung-Ang University Gwangmyeong Hospital, Gyeonggi-do, Republic of Korea; Department of Anesthesiology and Pain Medicine, College of Medicine, Chung-Ang University, Seoul, Republic of Korea.
与普罗波相比,雷米马佐拉姆麻醉与弗鲁马泽尼尔逆转显著加快了患者的出现. 然而,在麻醉后护理单位 (PACU) 进行复静需要进一步调查,以实现最佳使用.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
背景情况:
- 静脉内全麻醉 (TIVA) 在外科手术中很常见.
- 普罗波福和雷米马佐拉姆是广泛使用的麻醉剂.
- 弗卢马泽尼尔是一种用于逆转的二胺抗体.
研究的目的:
- 为了比较基于propofol和remimazolam的TIVA与flumazenil逆转的出现概况.
- 评估恢复意识的时间和其他相关的临床结果.
主要方法:
- 一项前性,双盲,随机对照试验,涉及100名成年患者 (ASA I-III).
- 患者接受了普罗波福或雷米马佐拉姆输液与雷米芬坦尼尔.
- 弗卢马泽尼尔用于在雷米马佐拉姆组的出现.
主要成果:
- 出现时间 (服从口头命令的时间) 与普罗波 (14 分钟) 相比,与雷米马佐拉姆 (5 分钟) 相比,显著缩短.
- 双光谱指数 (BIS) > 80和喉膜呼吸道 (LMA) 移除的时间也较短,使用雷米马佐拉姆.
- 在PACU中,在里士满兴奋镇静量表 (RASS) 评分中发现了显著的差异,其中22%的雷米马佐拉姆患者经历了重新镇静.
结论:
- 基于Remimazolam的TIVA与flumazenil逆转加速从全身麻醉中出现.
- 在PACU中重新镇静的发生率需要进一步的研究,以优化flumazenil的剂量和时间.
- 需要进行进一步的研究,以最大限度地提高效益,同时最大限度地降低恢复镇静的风险.
更多相关视频
08:49Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
Published on: October 16, 2013
08:16Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics
Published on: July 23, 2020
相关概念视频
Parenteral Anesthetics: Overview
General Anesthesia: Overview
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Inhalational Anesthetics: Overview
Stages of General Anesthesia
Sedatives and Hypnotics Drugs: Miscellaneous Agents
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Sedatives and Hypnotics Drugs: Benzodiazepines
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...
