怀孕和哺乳期间不同摄入量对母性和后代大鼠甲状腺和心血管功能的影响
Xiuxiu Zhao1, Yue Sun1, Hexi Zhang2
1Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
概括
怀孕和哺乳期间高摄入会影响母亲的甲状腺和心血管功能,增加血压并改变心脏功能. 后代显示脂肪酸代谢发生变化,但没有显著的心血管变化.
科学领域:
- 内分泌学 在内分泌学.
- 心血管生理学心血管生理学
- 营养科学 营养科学
背景情况:
- 对于甲状腺激素的合成至关重要,对母亲和胎儿的发育至关重要.
- 怀孕和哺乳期增加了对的需求,使母亲的摄入量变得至关重要.
- 过多的酸盐摄入会破坏甲状腺功能,并可能影响心血管健康.
研究的目的:
- 调查怀孕和哺乳期不同摄入量对母鼠和后代大鼠的影响.
- 评估对度,甲状腺和心血管功能以及脂肪酸代谢的影响.
主要方法:
- 在整个孕期和哺乳期,孕妇大鼠接受正常或高摄入量 (正常的5倍或10倍).
- 测量包括尿液和血清,甲状腺激素 (FT3),心脏功能 (心声),血压和基因/代谢物表达 (KLF9,Txnrd2,脂肪酸).
主要成果:
- 高摄入量增加了母亲和后代的度,母亲的FT3和KLF9表达.
- 母鼠的血压升高和心脏功能过高,与水平和KLF9/Txnrd2表达相关.
- 后代表现出改变的血清和增加的EPA代谢物,但血压或心脏功能没有显著变化.
结论:
- 怀孕和哺乳期间高摄入量显著影响母亲的甲状腺和心血管系统.
- 血清总度 (STIC),非蛋白质结合度 (SNBIC),KLF9,Txnrd2和特定代谢物可以作为生物标志物.
- 需要进一步的研究来了解高摄入量的长期影响和具体机制.
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