与大麻素作为药物耐药性的附加治疗的现实世界经验
Walter Vicino1, Lorenzo Muccioli1, Federica Pondrelli1
1Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Seizure
|July 28, 2023
概括
大麻 (CBD) 在现实环境中有效降低了耐药患者的发作频率. 超过一半的人经历了不良事件,但CBD被证明是一种安全有效的治疗选择,即使是非标签用途.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 发病学 (Epileptology) 是一个专业的学科.
背景情况:
- 是一种慢性神经系统疾病,其特点是经常性发作.
- 耐药性带来了重大治疗挑战,需要探索新的治疗药物.
- 大麻素 (CBD) 是来自大麻sativa的非精神活性化合物,在管理方面表现有前途.
研究的目的:
- 评估大麻 (CBD) 在患者的实际有效性和安全性.
- 评估与CBD治疗相关的发作频率减少和不良事件.
- 确定CBD治疗在不同患者群体中的保留率和长期结果.
主要方法:
- 追溯观察性研究,包括2019年3月至2022年11月期间处方CBD的患者.
- 3,6个月和12个月的后续评估,通过减少发作频率 (>30%至<80%) 和超级响应者 (≥80%) 来定义响应者.
- 记录不良事件和同时服用抗发作药物的记录,以评估安全性和治疗复杂性.
主要成果:
- 包括42名患者 (平均年龄36.1岁),其中24名接受标签上和18名非标签CBD处方.
- 3个月后,23%是响应者,29%是超级响应者,在12个月后持续有效.
- 52.3%的人经历了不良事件 (嗜睡,腹最常见);保留率仍然很高 (71.4%在12个月).
结论:
- 大麻 (CBD) 已在现实环境中证明其安全性和有效性,作为高度耐药性患者的治疗选择.
- CBD导致发作频率显著降低,包括那些没有标签说明的患者.
- 这项研究支持CBD作为耐火性的有价值治疗方法,尽管存在潜在的不良事件.
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