长非编码RNA在乳腺癌微环境中的作用
Wenwu Yao1, Lin Wang2, Fang Liu3
1Institute of Hematological Disease, Jiangsu University, Zhenjiang 212001, China; International Genome Center, Jiangsu University, Zhenjiang 212013, China.
Pathology, research and practice
|July 28, 2023
概括
长非编码RNAs (lncRNAs) 在乳腺瘤微环境 (TME) 中发挥着至关重要的作用. 这些分子影响瘤的进展,并有可能作为乳腺癌的诊断标记物.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 瘤微环境 (TME) 包括各种细胞和影响瘤生长和转移的因素.
- 长非编码RNAs (lncRNAs) 与细胞过程和癌症进展有关.
- 异常的lncRNA表达与乳腺癌的发展有关,并作为诊断标记.
研究的目的:
- 总结 lncRNAs 在乳腺癌微环境中的作用.
- 探索TME和lncRNAs之间的相互调节.
- 突出TME相关 lncRNAs 在乳腺癌的诊断潜力.
主要方法:
- 文献综述和现有关于lncRNAs和乳腺TME的研究的综合.
- 对研究 lncRNA 参与瘤细胞,纤维细胞和免疫细胞相互作用的研究进行分析.
- 检查乳腺癌中lncRNA失调的证据及其与TME组件的相关性.
主要成果:
- 来自瘤和非瘤细胞的lncRNAs调节乳腺瘤的生长,增殖和迁移.
- TME相互调节瘤细胞,纤维细胞和巨细胞中的lncRNA表达,影响它们的功能.
- 乳腺癌中 lncRNAs 的调节失调,影响了 TME 的动态.
结论:
- 与TME相关的lncRNAs在乳腺癌进展中起着关键作用.
- lncRNAs代表了乳腺癌的有前途的诊断和治疗点.
- 需要进一步的研究来阐明确切的分子机制,规范lncRNA-TME相互作用.
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