由 ceftriaxone 预处理引起的对肝脏代谢的长期影响
Chengze Lai1, Linkang Chen2, Xiaoting Zhong2
1The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, China; Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan, China.
Environmental pollution (Barking, Essex : 1987)
|July 28, 2023
概括
暴露于Ceftriaxone (Cef) 可以通过改变肠道微生物群和新陈代谢而导致肝损伤. 这项研究揭示了Cef诱导的肠道失调和随后的小鼠肝脏代谢障碍,突出了潜在的危害机制.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 肝病学 肝病学是一种肝病学.
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
背景情况:
- 塞夫特里亚 (Cef) 是一种新出现的污染物,具有潜在的健康风险,特别是它对肝功能的影响.
- 对于Cef影响肠肝轴的确切机制尚不完全理解,需要进一步研究.
- 建立一个可靠的动物模型对于阐明Cef的肝毒性作用和潜在途径至关重要.
研究的目的:
- 在小鼠模型中研究高剂量氏 (Cef) 对肝脏和肠道代谢的作用.
- 探索肝脏新陈代谢,肠道新陈代谢和由Cef.诱导的微生物变化之间的相关性.
- 通过肠肝轴阐明Cef诱导的肝损伤的潜在机制.
主要方法:
- 在C57BL/6J小鼠中建立肠道失调模型,使用高剂量的Cef预处理,然后进行恢复期.
- 在便和肝脏样本上应用非向的代谢学 (包括脂质学).
- 便短链脂肪酸 (SCFA) 和胆汁酸 (BA) 的有针对性的确定,加上相关性和调解分析.
主要成果:
- Cef预治疗减少了体重增加和肝体指数,诱导了肝脏病体学变化,并改变了BCAA与AAA的比例.
- 便代谢表显示黄油酸减少和初级胆酸增加,尽管总SCFA和BA没有显著变化.
- 相关性分析表明,CEF破坏肠道微生物群,导致肠道新陈代谢发生变化 (例如,乙酸盐,酸盐) 和随后的肝脏代谢障碍 (例如,精子素,因诺辛).
结论:
- 塞夫特里亚克松暴露可以诱导肝损伤,由小鼠的代谢和组织学变化证明.
- 该研究提供了Cef暴露后肝脏的综合代谢概况.
- 一个潜在的机制涉及Cef诱导的肠道失调,它通过肠肝轴调解肝脏代谢功能障碍.
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