胃肠道出血和血管新生转移在血管蛋白轴与连续流动的左心室辅助装置植入装置

胃肠道出血和血管新生转移在血管蛋白轴与连续流动的左心室辅助装置植入装置

相关实验视频

Updated: Jul 21, 2025

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

06:10

Utilizing Percutaneous Ventricular Assist Devices in Acute Myocardial Infarction Complicated by Cardiogenic Shock

Published on: June 12, 2021

3.3K

Adam L Edwards¹, C Mel Wilcox¹, Mark Beasley²

¹Division of Gastroenterology and Hepatology, Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

The American journal of the medical sciences

|July 28, 2023

概括

患有胃肠道出血 (GIB) 的持续流动左心室辅助器件 (CF-LVAD) 接受者表现出血管蛋白水平的改变. 较低的血管蛋白-1和较高的血管蛋白-2与GIB有关,可能与低脉压有关.

科学领域:

心血管科学心血管科学
血管生物学血管生物学
胃肠病学胃肠病学

背景情况:

胃肠道出血 (GIB) 影响着高达40%的连续流动左心室辅助器件 (CF-LVAD) 接受者.
低器械脉动性是CF-LVAD患者GIB的风险因素,但根本机制尚不清楚.
在CF-LVAD接受者的血液动力学变化可能会影响血管生成信号.

研究的目的:

测量CF-LVAD接受者与没有GIB和健康对照中的血管蛋白 (Ang) -1,Ang-2和VEGF-A的血清水平.
评估CF-LVAD接受者的这些血管蛋白水平和血液动力学参数之间的相关性.

主要方法:

招募了12名CF-LVAD接受者 (6名GIB) 和12名年龄匹配的对照.
测量了血清中的Ang-1,Ang-2和VEGF-A水平.
与设备血液动力学相关的血管蛋白水平,包括脉冲压.

主要成果:

与对照组相比,CF-LVAD受体的Ang-2水平较高,Ang-1水平较低;VEGF-A水平相似.
患有GIB的CF-LVAD接受者与没有GIB的人相比,Ang-1水平较低.
趋势表明,CF-LVAD接受者的脉冲压与Ang-1正相关,与Ang-2负相关.

结论:

接受CF-LVAD的人在血管蛋白轴上表现出亲血管性转移.
这种转变与GIB显著相关,并可能与低脉压有关.
了解这些血管变化可能会为减少CF-LVAD患者GIB的策略提供信息.

关键词:

血管新生素 (Angiopoietin) 是一种血管新生素.胃肠道出血胃肠道出血左心室辅助装置的使用

更多相关视频

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock

07:39

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock

Published on: August 16, 2021

3.7K

Implantation of the Syncardia Total Artificial Heart

16:11

Implantation of the Syncardia Total Artificial Heart

Published on: July 18, 2014

35.3K

相关概念视频

Regulation of Angiogenesis and Blood Supply

01:24

Regulation of Angiogenesis and Blood Supply

2.6K

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...

2.6K

01:10

Mechanism of Angiogenesis

5.6K

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...