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Updated: Jul 21, 2025

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通过抑制PPM1B的招募,TXLNA增强了TBK1的酸化

Xiao Tian1, Zhiyuan Zhang1, Ming Ding1

  • 1School of Life Science and Technology, China Pharmaceutical University, Nanjing 211199, China.

Biochimica et biophysica acta. Molecular cell research
|July 28, 2023
PubMed
概括

坦克结合激酶1 (TBK1) 在免疫和癌症中至关重要. 这项研究揭示了TXLNA损害了PPM1B与TBK1的结合,抑制了脱酸化并增强了瘤中的TBK1活性,提供了一个新的治疗点.

关键词:
在APEX2中,APEX2是APEX2的第二个版本.生物ID BioID 是一个生物ID.这就是PPM1B.在TBK1中,这是一个TXLNA.

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