移植与冠状病毒疾病2019-阳性捐赠者肺部是否安全? 一个美国全国性的分析
Richa Asija1, Ruby Singh2, Dane C Paneitz2
1Division of Cardiac Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Division of Thoracic Surgery, Columbia University Irving Medical Center, New York, New York.
The Annals of thoracic surgery
|July 28, 2023
概括
来自最近COVID-19的捐赠者的肺移植可能是安全的. 来自COVID-19阳性捐赠者的肺接受者的短期生存结果与来自阴性捐赠者的肺存活结果相似.
科学领域:
- 移植免疫学 移植免疫学
- 传染病研究传染病研究.
- 肺部医学 肺部医学
背景情况:
- 冠状病毒疾病2019 (COVID-19) 导致严重的肺衰竭,导致对使用感染个体的捐赠肺部产生犹.
- 这项研究调查了肺移植的安全性和结果,使用最近COVID-19阳性测试结果的捐赠者.
研究的目的:
- 分析最近出现COVID-19阳性检测的捐赠者的肺移植的特征和短期结果.
- 为了比较COVID-19阳性和阴性捐赠者的肺接受者之间的生存率和外科并发症.
主要方法:
- 从2020年1月到2022年6月使用联合器官共享网络数据库对肺移植进行了回顾性分析.
- 排除了儿科,多器官和重复的肺移植.
- 倾向性比分匹配比较COVID-19阳性捐赠者的肺接受者与COVID-19阴性捐赠者的接受者,分析30天和3个月死亡率和外科术后结果.
主要成果:
- 在5270例肺移植中,51例涉及最近出现COVID-19阳性检测的捐赠者.
- 在倾向性得分匹配后,来自COVID-19阳性捐赠者的45名接受者与来自COVID-19阴性捐赠者的135名接受者进行了比较.
- 没有观察到30天或3个月死亡率的显著差异,也没有观察到两组之间术后并发症的发生率.
结论:
- 从最近出现COVID-19阳性检测的捐赠者移植的肺部移植显示了类似的短期存活结果,与负面捐赠者的短期存活结果相似.
- 没有活跃感染的高度选择的COVID-19阳性捐赠者可能会被考虑进行肺移植.
- 建议对长期结果进行进一步的研究,以确认这种做法的安全性.
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