种族特异性螺旋测量方程并不能改善呼吸不良的模型和定量胸部CT现象型
Amy L Non1, Barbara Bailey2, Surya P Bhatt3
1Department of Anthropology, University of California San Diego, La Jolla, CA.
Chest
|July 28, 2023
概括
特定于种族的肺功能方程并不能改善CT扫描异常或COPD严重程度的预测. 种族中立或没有种族的方程可以提高弱势群体的诊断和治疗.
科学领域:
- 肺部医学 肺部医学
- 医学诊断 医学诊断 医学诊断
- 健康差异 在健康上的差异
背景情况:
- 螺旋测量参考方程对于解释肺功能至关重要,通常包含种族.
- 将种族纳入这些方程中的问题越来越多地受到辩论和审查.
- 准确的肺功能评估对于诊断和管理呼吸系统疾病至关重要.
研究的目的:
- 为了确定自认的种族在螺旋测量方程中是否改善了定量胸部CT异常,呼吸不全或COPD分类的预测.
- 为了比较特定种族,种族中立和种族自由的螺旋测量方程的性能.
主要方法:
- 使用健康,非吸烟成年人的数据生成了种族特定,种族中立和种族自由的FEV1预测方程.
- 通过横截面分析将这些方程应用于吸烟人群.
- 利用灵敏度/特异性,物流回归和随机森林模型来评估模型适合CT表型,呼吸障碍和GOLD分类.
主要成果:
- 特定于种族的方程在预测CT表型或呼吸障碍方面没有比种族中立或无种族方程提供任何优势.
- 种族中立方程式将高达19%的黑人参与者重新分类到更严重的COPD阶段.
- 与种族特异性方程相比,种族中立/无种族方程显示了改进模型适合呼吸障碍症状的潜力.
结论:
- 特定于种族的螺旋测量方程式在预测肺部疾病指标方面没有比种族中立或无种族替代品提供可证明的优势.
- 种族中立/无种族方程可以提高肺部疾病诊断和治疗的准确性,特别是在高风险人群中.
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