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在极度早产的婴儿中出现的B组菌感染:作为早产新生儿,婴儿和幼儿
Ina Schim van der Loeff1,2, Christo Tsilifis3,2, Khalid Abdelhafiz4
1Paediatric Immunology and Infectious Diseases, Great North Children's Hospital, Newcastle upon Tyne, UK ina.schim@nhs.net.
BMJ case reports
|July 28, 2023
概括
尽管接受了治疗,但在早产婴儿中发生了重复的B组链球菌 (GBS) 感染. 观察到母乳GBSDNA和过渡性低二球蛋白血症,突出显示了早产婴儿的风险.
科学领域:
- 新生儿感染 新生儿感染
- 儿童传染病 儿童传染病
- 细菌病原体的发生.
背景情况:
- 乙组链球菌 (GBS) 是新生儿和婴儿侵袭性细菌感染的主要原因.
- 过早出生的婴儿特别容易受到严重和复发的GBS疾病的影响.
- 在 GBS 感染中,母乳等母因子在 GBS 感染中所起的作用尚不完全理解.
研究的目的:
- 描述一个极其早产婴儿中复发性GBS细菌病的病例.
- 调查GBS复发的潜在来源和促成因素.
- 突出在高风险婴儿中管理侵入性GBS疾病的挑战.
主要方法:
- 病例报告详细介绍了复发性GBS细菌病的临床过程,调查和治疗.
- 聚合酶链反应 (PCR) 用于检测母乳中的GBS 16S DNA.
- 进行了放射学和免疫学检查.
- 针对GBS分离物的全基因组测序.
主要成果:
- 在从婴儿到幼儿时期的极度早产婴儿身上,发生了五次独立的GBS细菌病发作.
- 在母乳中检测到GBS 16S DNA,并从婴儿和母亲中分离出相同的GBS血清型.
- 婴儿时期的过渡性低二球蛋白血症被确定,但得到了解决.
- 在放射学上没有确定GBS复发的特定焦点.
结论:
- 反复发生的GBS细菌病症可能会导致早产婴儿的显著发病率.
- 母乳可能在持续或复发的GBS感染中起作用.
- 管理需要采取全面的方法,考虑宿主因素和潜在的水库.
- 及时识别和有效的抗微生物治疗对于GBS感染至关重要.
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