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在英国,COVID-19流行病对接受治疗性放射治疗的肺癌患者的结果的影响

I Fornacon-Wood¹, K Banfill², S Ahmad³

¹University of Manchester, Manchester, UK.

Clinical oncology (Royal College of Radiologists (Great Britain))

|July 28, 2023

概括

对肺癌患者的COVID-19流行病治疗变化没有显著影响生存率或远程复发. 然而,改变放射治疗,特别是低分离,增加了肺癌患者的急性毒性.

科学领域:

在瘤学瘤学.
辐射疗法辐射疗法
公共卫生公共卫生

背景情况:

由于COVID-19大流行,标准癌症护理需要改变,这影响了接受放射治疗的肺癌患者.
之前的研究表明,在英国,这些患者中很大一部分的治疗方法发生了显著的改变.

研究的目的:

评估COVID-19相关治疗变化对肺癌患者治疗结果的影响.
评估对生存,远程复发和毒性的影响.

主要方法:

未来的多中心英国队列研究 (COVID-RT肺部数据库) 对I-III期肺癌患者进行激进放射治疗 (2020年4月至10月).
使用多变量Cox和逻辑回归分析来评估放射治疗变化和化疗缺失对结果的影响.

主要成果:

在I-II阶段非小细胞肺癌 (NSCLC) 中,放射治疗变化没有显著影响远程复发或生存,但增加了≥3级急性毒性.
在III期NSCLC中,放射治疗的改变没有显著影响远程复发或生存,但增加了≥3级急性毒性.
在第三阶段NSCLC中放弃化疗并没有显著增加远程复发或死亡.

结论:

在COVID-19大流行期间的治疗修改并没有对肺癌患者的生存率或远程复发率产生不利影响.
在放射治疗中增加的低分离率导致急性毒性的更高率.
研究结果支持使用低分离放射治疗来减少紧急情况下的医院访问.

关键词:

在 COVID-19 疫情中,化疗化疗是一种化学疗法.低分化是一种低分化.肺癌是一种肺癌.辐射疗法辐射疗法减少的分化减少的分化.

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