在非酒精性脂肪肝疾病中的定量超声波参数的诊断性能
Mehnoosh Torkzaban1, Corinne E Wessner1, Dina Halegoua-DeMarzio2
1Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107 (M.T., C.E.W., A.L., K.N.).
Academic radiology
|July 28, 2023
概括
超声波参数衰减系数 (AC) 和肝硬度 (LS) 准确地检测非酒精性脂肪肝疾病 (NAFLD) 中的肝硬化和纤维化. 结合AC和LS可以提高NAFLD和高风险患者的诊断准确度.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 医疗成像医学成像
- 诊断性的超声波检查
背景情况:
- 非酒精性脂肪肝 (NAFLD) 存在重大健康风险,晚期脂肪,脂肪肝炎和纤维化与不良结果相关.
- 准确的非侵入性诊断NAFLD并发症对于患者管理至关重要.
研究的目的:
- 评估超声波衍生衰减系数 (AC),肝硬度 (LS) 和分散斜率 (DS) 的诊断性能,用于怀疑NAFLD患者的肝硬化和纤维化.
- 评估这些超声波参数的联合诊断实用性,使用活检或MRI作为参考标准.
主要方法:
- 74名NAFLD疑似患者使用Aplio i800扫描仪进行了超声波成像,获得了AC,LS和DS测量.
- 诊断性能与肝脏活检 (34名患者) 或核磁共振 (40名患者) 相比进行了评估.
主要成果:
- AC和LS分别表现出高诊断价值的肥胖症和纤维化.
- 结合AC和LS的AUROCC达到0.87用于检测肥胖症和纤维化 (S+F).
- 仅LS就显示了AUROCC为0.93,用于检测晚期纤维化 (阶段≥2). 结合AC,LS,DS和BMI,在检测非酒精性脂肪肝炎 (NASH) 时实现了0.87的AUROCC.
结论:
- 超声波参数AC和LS对于检测NAFLD肝脏肥胖症和纤维化有价值.
- 结合AC和LS可以提高诊断准确度,用于识别NAFLD和高风险个体.
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