生物成分的鉴定,用于组织圆形多层状的sialolith形成
Buyanbileg Sodnom-Ish1, Mi Young Eo1, Yun Ju Cho1
1Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Research Institute, Seoul National University, Seoul, Korea.
Scientific reports
|July 28, 2023
概括
这项研究揭示了石 (唾液石) 形成在含有外体和细菌的中心体周围,导致化和阻塞. 了解这些生物成分有助于诊断和治疗唾液腺结石.
科学领域:
- 口腔生物学和病理学
- 生物矿物化的研究研究.
- 生物材料科学是生物材料的科学.
背景情况:
- 石或唾液结石因其独特的超结构和化学成分而与其他结石 (例如,胆石,尿石) 不同.
- 之前的研究还没有完全阐明石灰石的生物成分和形成过程.
研究的目的:
- 为了确定sialoliths的生物成分和超结构.
- 阐明石灰岩的形成机制,使其与其他石头类型区分开来.
主要方法:
- 组织学检查来自20名患者的22个sialolith样本.
- 使用微计算断层扫描 (micro-CT),扫描电子显微镜 (SEM),能量分散式X射线光谱 (EDS) 和传输电子显微镜 (TEM) 的分析.
主要成果:
- 石灰岩石表现出一个中央,富含有机体基质,外体囊泡,酸盐晶体和细菌.
- 微CT和SEM揭示了围绕巢穴的化紧区域,因炎症和化水平而变化.
- TEM在巢穴中发现了外体囊泡和降解的有机细胞,而EDS在紧区域显示了高的Ca/P比率.
结论:
- 中部,包含炎症外体和细胞碎片,启动带状化.
- 随后的上皮细胞和唾液材料的沉积有助于sialolith的生长和唾液流的阻塞.
- 石形成涉及一个独特的生物过程,与其他类型的微积分不同,促进细菌感染.
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