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Updated: Jul 21, 2025

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans
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Published on: September 7, 2021

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通过蛋白质稳定机制调节p38 MAPK信号,支持生长和衰老期间的组织完整性

Wang Yuan1, Yi M Weaver1, Svetlana Earnest1

  • 1Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX, USA.

Nature communications
|July 28, 2023
PubMed
概括

p38 MAPK信号传递,特别是C. elegans中的PMK-1,通过调节非化PMK-1水平,促进长寿和神经元完整性,在衰老过程中动态支持组织平衡.

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