中腰部 (L3) 外周刺激对未受伤和慢性切割尿麻醉的老鼠的膀和外部尿道缩器的影响
Daniel Medina-Aguiñaga1, Robert F Hoey1,2,3, Natasha L Wilkins1
1Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, 511 S. Floyd St., MDR, Room 111, Louisville, KY, 40202, USA.
Scientific reports
|July 28, 2023
概括
在L3水平的脊髓外周刺激 (scES) 可以调节膀和外泌尿道关的功能. 这种技术在完整和脊髓受伤 (SCI) 个体中增强空洞的承诺.
科学领域:
- 神经科学是一个神经科学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 再生医学是一种再生医学.
背景情况:
- 脊髓外周刺激 (scES) 已显示出改善下泌尿道 (LUT) 功能的潜力.
- 之前的研究针对的是胸和腰神经区域,但通过腰部中部刺激调节外部尿道 (EUS) 的研究仍然较少.
研究的目的:
- 调查中腰部 (L3) scES对EUS功能和空洞模式的影响.
- 评估L3 scES在完整和慢性脊髓损伤 (SCI) 的雌性大鼠中的疗效.
主要方法:
- 在尿麻醉下,对完整和慢性完整的SCI雌性大鼠进行了L3脊髓外周刺激.
- 使用囊泡测量监测空洞模式,包括空洞体积和EUS活动.
- 在SCI之后,大鼠根据LUT功能障碍被分为子组.
主要成果:
- 在完整的老鼠中,L3 scES减少了空洞体积和EUS爆发时间.
- 在SCI大鼠中,L3 scES在不同的LUT功能障碍子组中引起了不同的囊泡测量结果和改变了EUS破裂模式.
- 刺激对膀和EUS都表现出神经调节作用.
结论:
- 在完整和SCI大鼠中,L3 scES可以功能地调节泌尿膀和EUS.
- 这种方法有可能在各种临床环境中增强空化和管理LUT功能障碍.
- 准L3脊柱段提供了一个有前途的策略,用于神经调节排尿.
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