氨酸甲基化与冲动和反社会行为有关:依赖基变异,家庭环境和饮食
Margus Kanarik1, Katre Sakala2,3,4, Denis Matrov5
1Division of Neuropsychopharmacology, Institute of Chemistry, Faculty of Science and Technology, University of Tartu, Ravila 14A Chemicum, 50411, Tartu, Estonia.
Journal of neural transmission (Vienna, Austria : 1996)
|July 28, 2023
概括
单胺氧化酶A (MAO-A) 基因甲基化,特别是CpG3,与男性的冲动行为有关. 这种表观遗传标记可能表明神经可塑性,受遗传学,环境和饮食的影响.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 精神病学是一个精神病学.
背景情况:
- 单胺氧化酶A (MAO-A) 缺乏与反社会行为有关.
- 低表达性MAOA uVNTR基因型 (MAOA-L) 和童年虐待与男性的冲动性表型有关.
- 基因甲基化是将家庭环境与行为联系起来的潜在机制.
研究的目的:
- 研究MAOA甲基化与男性冲动性/反社会行为的关系.
- 探索MAOA基因型和环境因素对这种关联的影响.
- 研究MAOA甲基化与冲动性相关的发育动态.
主要方法:
- 在121名男性中评估了12个CpG位点的MAOA甲基化.
- 与冲动性/反社会行为,酒精使用障碍和家庭环境相关的甲基化水平.
- 研究了不同年龄 (15,18,25) 和MAOA基因型 (MAOA-L,MAOA-H) 的相关性.
- 研究了MAOA CpG3甲基化与饮食中微量营养素摄入之间的联系.
主要成果:
- 较低的MAOA CpG3甲基化与涉及警察接触的反社会行为有关.
- 在25岁时患有酒精使用障碍的受试者中,CpG3甲基化水平较低,特别是MAOA-H基因型.
- 在MAOA-L基因型中,MAOA CpG3甲基化和适应性冲动性之间的正相关性在18岁时出现,在不利的家庭环境中在25岁时加强.
- 对于不适应性冲动性来说,MAOA CpG3甲基化动态有所不同,在18岁时存在关联,但在25岁时不存在.
- CpG3甲基化与饮食中摄入的,,,维生素E和有相关性.
结论:
- MAOA CpG3甲基化与青春期的不适应性和适应性冲动性有关,对于具有不利家庭环境的MAOA-L雄性.
- 与不适应性冲动性的关联在年轻成年后减少,而与适应性冲动性的联系则加强.
- 在MAOA-L基因型中,MAOA CpG3甲基化可能作为适应性发育神经可塑性的生物标志物.
- 饮食因素可能在观察到的表观遗传机制中起作用.
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