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免疫微环境和淋巴结在结直肠癌中产生

Soo Hyun Lee¹, Amaya Pankaj², Azfar Neyaz^3,4

¹Department of Pathology, Boston Medical Center, Boston, MA, USA.

British journal of cancer

|July 28, 2023

概括

在结直肠癌患者中,更高的淋巴结 (LN) 产量与更强大的免疫微环境和更好的生存率相关. 这表明瘤.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
癌症研究癌症研究

背景情况:

淋巴结 (LN) 收获对于结直肠癌的分期和预后至关重要.
主要瘤的免疫微环境与LN产量之间的关系仍未得到充分研究.

研究的目的:

调查瘤的免疫微环境是否与结直肠腺癌中的淋巴结 (LN) 产量有关.
确定LN产量的预后意义及其与免疫标记物的相关性.

主要方法:

对比了926名未经治疗的结直肠腺癌患者,LN产量高 (≥12) 与低 (<12) .
在组织微阵列上利用免疫组织化学来量化免疫标记物,包括CD8,PD-L1和β-2-微型血球蛋白 (B2MG).

主要成果:

较高的LN产量 (LN-高) 与年轻患者,较大的瘤,右侧位置和缺陷不匹配修复 (dMMR) 有关.
高LN组表现出增加的CD8+T细胞透和B2MG表达.
在LN高的组中,疾病特异性生存率显著更高.

结论:

增加LN产量与结直肠癌的生存益处有关.
瘤的LN产量与免疫丰富的瘤微环境有关,这表明免疫因素会影响瘤的LN产量.
瘤的LN产量,CD8+细胞透和瘤阶段是独立的预后因素.

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