中央视网膜动脉封闭患者中血栓性风险因素的高患病率
Radosław Dziedzic1,2, Lech Zaręba3, Teresa Iwaniec4
1Doctoral School of Medical and Health Sciences, Jagiellonian University Medical College, Łazarza 16, Krakow, 31-530, Poland.
Thrombosis journal
|July 28, 2023
概括
血栓友好症显著导致视网膜中枢动脉封闭 (CRAO),这是导致失明的主要原因. 查遗传性和获得性血栓型风险因素对于预防CRAO发作至关重要.
科学领域:
- 眼科医生 眼科 眼科
- 血管医学 血管医学
- 血液学 血液学 血液学
背景情况:
- 中央视网膜动脉封闭 (CRAO) 是视力丧失的主要原因,通常与血栓事件有关.
- 遗传性和获得性血栓型风险因素对CRAO的贡献尚未完全理解.
研究的目的:
- 调查CRAO患者中血栓性风险因素的患病率.
- 评估各种血栓性标记物与CRAO发展之间的关联.
主要方法:
- 评估了126名CRAO患者和107名对照人群的传统动脉样硬化风险因素,动脉内心介质厚度和心声学参数.
- 评估遗传性 (V Leiden因子,前列血20210 G/A) 和获得的血栓性因子 (抗脂抗体,蛋白C,抗血,自由蛋白S,同素,FXIII-A Val34Leu).
主要成果:
- 在CRAO患者中,肥胖,高胆固醇血症,高密度介质厚度和腹功能障碍的发生率较高.
- 在CRAO患者中观察到血栓友的显著患病率,其中抗脂抗体 (APLA) 最常见 (38.1%),其次是蛋白C (17.5%) 和自由蛋白S缺乏 (19.8%).
- 莱登V因子 (FVL) 和高血糖血与CRAO显著相关,而抗血素缺乏,FVIII升高和FXIII-A Val34Leu没有.
结论:
- 血栓友是CRAO病变发生的一个关键因素.
- 为预防和管理CRAO,建议进行血栓性风险因素的常规实验室查.
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