凝血生物标志物和冠状病毒疾病2019年表型化:一个前性队列研究
Emily Corneo1, Rafael Garbelotto1,2, Gabriele Prestes1
1Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Santa Catarina, Av. Universitária, Criciúma, 1105, Brazil.
Thrombosis journal
|July 28, 2023
概括
像抗血和C反应蛋白 (CRP) 这样的凝血标志物与COVID-19的严重程度和生存有关. 使用这些生物标志物的特定患者表型的识别可以指导针对性干预,以获得更好的结果.
科学领域:
- * 血液学和血栓形成
- * 传染病和病毒学
- * 关键护理医学 关键护理医学
背景情况:
- * 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 感染与显著的发病率有关,包括血栓形成.
- *评估凝血标志物对于了解COVID-19预后和患者表型是非常重要的.
研究的目的:
- * 调查特定的凝血生物标志物与COVID-19重症监护室 (ICU) 患者的临床结果之间的关联.
- *根据凝血标志物水平及其与死亡率的相关性,识别出不同的患者表型.
主要方法:
- *对213名ICUCOVID-19患者进行前性研究,测量了抗血素,C反应蛋白 (CRP),XI,XII,XIII因子,前血素和D-二次体.
- *统计分析包括斯皮尔曼的相关性,等级和非等级集群分析 (K-平均值) 和多变量二进制回归.
主要成果:
- *较低的XI,XII,XIII因子和前列血栓水平与COVID-19严重程度的增加相关.
- *较高的XIII因子,抗血素和CRP水平与死亡率有关.
- *使用CRP和抗血水平确定了两个不同的患者表型,独立于临床变量,并与死亡率相关.
结论:
- *凝血生物标志物与COVID-19患者的住院生存有显著的相关性.
- * 特定的凝血标记特征 (如高CRP和抗血) 表明预后较差.
- *这些发现强调了凝血异常在COVID-19病变发生过程中的作用,并表明了针对特定患者亚组的向抗凝血药疗法的潜力.
相关概念视频
01:09Coagulation
7.1K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
7.1K
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
201
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
201
01:20Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
14
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
14
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
119
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
119
01:29Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
10
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
10
02:45Blood Transfusion and Agglutination
10.9K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
10.9K