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卢基配方通过改善HIF-1α介导的肠壁完整性来缓解心室重塑
Jirong Yan1, Zhichao Xi2,3, Jiaying Guo1
1Institute of Cardiovascular Disease of Integrated Traditional Chinese and Western Medicine, Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine, No. 528, Zhangheng Road, Shanghai, 201203, China.
Chinese medicine
|July 28, 2023
概括
卢基配方 (LQF) 通过保持肠道屏障的完整性,部分通过升调缺氧诱导因子-1α (HIF-1α) 来保护心脏功能. 这种传统中医药在心力衰竭 (HF) 治疗方面表现有前途.
科学领域:
- 心血管研究研究心血管研究
- 胃肠病学 胃肠病学
- 传统中国医药 传统中国医药
背景情况:
- 心室重塑,心脏应对压力的适应过程,可以导致心力衰竭 (HF),并与肠道屏障功能受损有关.
- 传统中医药LuQi配方 (LQF) 用于心室重塑和高血压,但其对相关肠道屏障功能障碍的影响尚不清楚.
研究的目的:
- 调查LQF在 Ventricular Remodeling期间保护肠道屏障完整性的作用.
- 探索涉及缺氧诱导因子-1α (HIF-1α) 的潜在机制.
主要方法:
- 在老鼠中诱导了心室重塑;评估了心脏功能,组织形态,细胞亡和炎症标志物.
- 分析了肠道透性,紧结蛋白和HIF-1α表达.
- 接受LQF治疗的HF患者的心脏功能和肠道透性标志物被评估.
主要成果:
- 在老鼠中,LQF改善了心脏功能,减少了心肌纤维化和亡,并保持了肠道屏障的完整性.
- LQF提高了结肠中的HIF-1α表达的调节,并且抑制HIF-1α降低了LQF的保护作用.
- 在LQF治疗后,HF患者的心脏功能得到改善,肠道透性标志物减少.
结论:
- 在心室重塑中,LQF通过保持肠道屏障完整性来保护心脏功能,部分通过HIF-1α上调调节进行调节.
- 通过解决心脏和肠道功能障碍,LQF证明了心力衰竭的治疗潜力.
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