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与抗氧化剂补充剂相关的化疗法可以减少多发性硬化症中的氧化应激和炎症:初步结果.

Alessandra Vezzoli1, Simona Mrakic-Sposta1, Cinzia Dellanoce1

  • 1Institute of Clinical Physiology, National Research Council (IFC-CNR), Piazza Ospedale Maggiore 3, 20159 Milano, Italy.

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概括

用EDTA和微量营养素进行抗氧化合疗法可以减少多发性硬化症 (MS) 患者的氧化应激和炎症. 这种治疗改善了氧性炎症的平衡,可能保护MS的轴突损伤和脱髓化.

关键词:
艾达达 (EDTA) 是一个叫做EDTA的语言.在EPR中使用EPR.这就是ROSOS ROS.细胞因子 细胞因子神经退行症的神经退行症神经毒性的作用.氧化损伤是因为氧化损伤.硫醇的氧化还原状态

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科学领域:

  • 神经免疫学 神经免疫学
  • 氧化压力研究研究 氧化压力研究
  • 临床营养学 临床营养学

背景情况:

  • 多发性硬化症 (MS) 的特征是轴突损伤和脱髓化,与氧-炎症失衡有关.
  • 氧化应激和炎症在MS的发病过程中起着至关重要的作用.

研究的目的:

  • 在MS患者中研究抗氧化剂治疗的有效性,使用二乙烯二胺酸 (EDTA) 化疗与微量营养素复合物相结合.
  • 评估这种治疗对氧化应激标志物,抗氧化能力和MS炎症状况的影响.

主要方法:

  • 招募了20名多发性硬化患者和20名健康对照人群 (CTR).
  • 使用电子磁共振测量了血反应性氧物种 (ROS) 生产和总抗氧化能力 (TAC).
  • 评估了抗氧化系统的活动,尿路氧化应激生物标志物,血细胞因子 (TNFα,IL-1β,IL-6),sICAM水平,氧化 (NO) 代谢,和TTR度.

主要成果:

  • 多发性硬化症患者表现出较高的ROS产量,氧化损伤,炎症生物标志物和NO代谢物,与CTR相比,TAC较低.
  • 在MS患者中,治疗显著降低了促炎性标记物 (sICAM1,TNF-α,IL6) 和脂质过氧化和DNA损伤的生物标记物.
  • 治疗导致ROS产量的减少和抗氧化能力的增加,转向更低的硫醇状态.

结论:

  • 使用EDTA和微量营养素的抗氧化化疗法在MS患者中显示出保护作用.
  • 治疗似乎通过减少氧化应激和增强抗氧化能力来恢复氧炎的平衡.
  • 这种方法有可能通过减轻氧化损伤和炎症来管理MS.