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纳米技术在解决氧化应激相关肝脏疾病方面的影响越来越大

Sathiyamoorthy Padmanaban¹, Durgasruthi Pully², Antony V Samrot³

¹Department of Biomedical Sciences and BioMedical Sciences Graduate Program (BMSGP), Chonnam National University Medical School, Gwangju 61469, Republic of Korea.

Antioxidants (Basel, Switzerland)

|July 29, 2023

概括

反应性氧物种 (ROS) 在肝脏疾病中至关重要. 纳米技术提供了有前途的纳米抗氧化剂来对抗氧化应激,并改善酒精和非酒精性脂肪肝炎等疾病的治疗方法.

科学领域:

生物化学生化学
纳米医学是一种纳米医学.
肝病学肝病学是一种肝病学.

背景情况:

活性氧物种 (ROS) 是生物系统的组成部分,影响着生存和衰退.
在脂肪肝炎等肝脏疾病中,ROS既起病因作用,又起后果作用.
酒精性脂肪肝炎 (ASH) 和非酒精性脂肪肝炎 (NASH) 是这种疾病的关键例子.

研究的目的:

探索在与氧化应激相关的肝脏疾病中准ROS形成的治疗潜力.
研究纳米技术在开发新型抗氧化剂策略中的作用.
为了强调外源抗氧化剂的必要性,当内源防御被压倒时.

主要方法:

对肝脏病理生理学中的ROS现有文献的综述.
对目前针对ROS的治疗策略的分析.
探索基于纳米技术的方法,特别是纳米抗氧化剂.
评估纳米复杂系统在向抗氧化剂输送方面的优势.

主要成果:

对针对肝脏疾病的ROS药物的兴趣日益增长.
哺乳动物系统拥有对ROS的内在抗氧化防御.
外源抗氧化剂随着肝脏状况的进展变得至关重要.
纳米技术提供高效的纳米抗氧化剂,改善了传递和准.

结论:

纳米技术为控制肝脏疾病中的ROS水平提供了一个有希望的策略.
纳米抗氧化剂通过有针对性的输送和减少泄漏提供了更高的有效性.
进一步探索纳米技术对于开发有效的治疗氧化应激相关肝脏疾病至关重要.

关键词:

这就是ROSOS ROS.抗氧化剂抗氧化剂是一种抗氧化剂.肝脏疾病是一种肝脏疾病.纳米颗粒是一种纳米粒子.氧化应激是一种氧化应激.

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