用酒副产品来使多乳酸功能化,用于生物医学应用
Lidia Verano-Naranjo1, Cristina Cejudo-Bastante1, Lourdes Casas1
1Chemical Engineering and Food Technology Department, Science Faculty, Wine and Agrifood Research Institute (IVAGRO), University of Cadiz, Puerto Real, 11510 Cadiz, Spain.
Antioxidants (Basel, Switzerland)
|July 29, 2023
概括
葡萄废物的生物活性化合物增强了可植入的聚合物,如聚乳酸 (PLA). 超临界流体技术有效浸这些天然提取物,改善抗氧化和抗炎性质,以更好地整合组织.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 自然产品化学 自然产品化学
背景情况:
- 可植入的聚合物面临着炎症和排斥等挑战.
- 结合天然化合物可以改善聚合物的生物相容性和组织反应.
- 葡萄酒制造的副产品是生物活性化合物的丰富来源.
研究的目的:
- 使用酒副产品开发生物活性聚乳酸 (PLA).
- 研究用葡萄提取物浸PLA的超临界流体技术.
- 评估改性PLA的抗氧化,抗微生物和抗炎性质.
主要方法:
- 使用超临界CO2与乙醇或水-乙醇辅溶剂从红葡萄葡萄汁中提取生物活性化合物.
- 使用超临界CO2辅助浸 (SSI) 和压 (PSI) 浸PLA细丝的浸.
- 在不同的条件下量化浸提取物的含量和评估生物活性 (抗氧化剂,抗微生物,抗炎).
主要成果:
- 这两种葡萄提取物都表现出显著的抗氧化,抗炎和抗菌能力,而乙醇提取物显示出更高的抗氧化活性.
- 浸负载达到了8% (提取物质量/聚合物质量),受提取物类型和压力/温度条件的影响.
- 使用乙醇提取物的加压浸泡方法 (PSI) 显著提高了PLA纤维的抗氧化能力,达到大约100μg TE/g PLA.
结论:
- 超临界技术提供了一条有效的途径,可以从造副产品中产生生物活性PLA.
- 浸的PLA表现出增强的抗氧化和抗炎性质,可能减少植入物排斥并促进组织愈合.
- 这种方法突显了利用农业废弃物用于先进的生物医学应用的潜力.
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