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BDE-47诱导线粒体功能障碍和内质网膜压力,以抑制早期猪胚胎发育

Rong-Ping Liu¹, Sheng-Yan He¹, Jing Wang^1,2

¹Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, Wuyi University, Jiangmen 529020, China.

Animals : an open access journal from MDPI

|July 29, 2023

概括

2,2′,4,4′-四博乙烯 (BDE-47),是一种阻燃剂,通过引起线粒体功能障碍和内分泌网膜应激,损害了猪早期胚胎发育. 这种环境污染物对生殖健康构成风险.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
发展生物学发展生物学

背景情况:

2,2′,4,4′-四二乙烯 (BDE-47) 是一种普遍存在的环境污染物,被用作阻燃剂.
BDE-47表现出已知的毒理作用,包括肝毒性,神经毒性,生殖毒性和内分泌干扰.
BDE-47对早期胚胎发育的影响需要进一步研究.

研究的目的:

调查BDE-47对猪早期胚胎发生的毒理效应.
阐明BDE-47引起的胚胎毒性的潜在机制.

主要方法:

在早期发育过程中,培养的猪胚胎暴露于BDE-47.
评估了胚胎细胞发生率,多能性基因表达,自标志物,氧化应激指标 (ROS,GSH),线粒体功能和内质网膜应激 (ERS) 标志物.
使用ESR抑制剂 (4-酸) 来评估其保护作用.

主要成果:

暴露在BDE-47下降了胚胎细胞的发育率和多能性基因mRNA水平.
观察到自标志物增加,ROS升高,抗氧化能力降低.
BDE-47诱导了线粒体功能障碍和内质网膜压力,由线粒体潜能降低和ER压力标志物增加证明.
ERS抑制逆转了BDE-47引起的ER损伤,并改善了胚胎质量.

结论:

在体外,BDE-47抑制了早期的猪胚胎发育.
线粒体功能障碍和内质网膜压力是BDE-47胚胎毒性的关键机制.
这些发现强调了与BDE-47暴露相关的潜在生殖风险.

关键词:

BDE-47 这是一本书.抗氧化剂是一种抗氧化剂.胚胎发育过程中的胚胎.细胞内膜网膜的内oplasmic网膜.线粒体中的线粒体.

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