3D打印的AgNPs和纳米TiO嵌入式基素的快速原型设计作为具有多响应性抗菌能力的新型设备,用于伤口愈合

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Giulia Remaggi¹, Laura Bergamonti², Claudia Graiff²

¹Food and Drug Department, University of Parma, Parco Area delle Scienze 27/a, 43124 Parma, Italy.

Antibiotics (Basel, Switzerland)

|July 29, 2023

概括

这项研究开发了新的3D打印伤口带,使用酸盐或酸盐中的银纳米粒子和二氧化. 这些创新的抗微生物支架有效地以可定制的精度治疗受感染的皮肤伤口.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
再生医学是一种再生医学.

背景情况:

受感染的皮肤伤口需要先进的治疗解决方案.
3D打印为伤口愈合提供了可定制的平台.
抗菌剂对于治疗伤口感染至关重要.

研究的目的:

开发和描述用于伤口包裹的新型3D打印水凝油墨.
将抗菌银纳米粒子 (AgNPs) 和二氧化 (TiO2) 纳入这些油墨中.
为了评估由此产生的3D打印脚手架的抗菌疗效和生物相容性.

主要方法:

使用AgNPs或TiO2与酸盐 (CH) 或酸盐 (ALG) 配制墨水.
宏的水凝支架的3D打印.
评估物理化学性质 (含水量,机械强度,形态).
针对金黄色葡萄球菌和Pseudomonas aeruginosa的抗菌检测.
使用人类纤维细胞活力测试进行生物相容性评估.

主要成果:

3D打印的脚手架表现出适用于伤口合剂的性能 (88-93%的含水量,0.23-0.6 MPa的模量).
AgNPs和TiO2显示出对格拉姆阳性和格拉姆阴性细菌具有显著的抗菌活性 (AgNPs MIC从5μg/mL开始).
基托桑基支架显示出比酸盐更高的生物相容性;AgNP (高达10μg/mL) 和TiO2没有显著影响细胞活力,而较高的AgNP度 (≥100μg/mL) 诱导了细胞毒性.

结论:

成功开发了新的,成本效益高的3D打印抗菌伤口包裹.
这些包裹提供精确的,可定制的解决方案,用于感染皮肤的伤口治疗.
这些发现支持这些支架在个性化抗菌药物中的潜在应用.

关键词:

通过3D打印打印3D打印.抗微生物活性的抗微生物活性.这种水凝是水凝.银纳米颗粒的使用方法二氧化二氧化的使用方法

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