COVID-19与ICU获得的血流感染之间的关系与多种耐药细菌有关
Antoine Piantoni1, Marion Houard1, Gaetan Piga1
1CHU de Lille, Service de Médecine Intensive Réanimation, F-59000 Lille, France.
Antibiotics (Basel, Switzerland)
|July 29, 2023
概括
COVID-19显著增加了重症监护室 (ICU) 中多药耐药细菌血流感染 (MDRB BSI) 的风险. 这种关联在ICU入院后的第15天起尤为明显.
科学领域:
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
- 流行病学 流行病学
背景情况:
- 血流感染 (BSI) 是一种严重的,经常在ICU获得的感染.
- 耐多药细菌 (MDRB) 是导致BSI的原因之一.
- COVID-19与二次感染有关,但其对MDRB BSIs的影响尚不清楚.
研究的目的:
- 评估COVID-19和由MDRB引起的ICU获得的BSI发生率之间的关系.
- 为了评估MDRB BSI在COVID-19患者中的风险,与非COVID-19患者在ICU中的风险相比.
主要方法:
- 一年多的回顾性,单中心研究.
- 包括在ICU住院的成年患者>48小时.
- 使用Kalbfleisch和Prentice方法进行累积发病率和因果特异性Cox的比例危险模型进行风险评估.
主要成果:
- 在1320名患者中,有497人患有COVID-19.
- 在50名患者中发生了MDRB BSI (36名COVID-19,14名非COVID-19患者).
- COVID-19与MDRB BSI (aHR 2.65) 的更高风险显著相关,特别是在入院后的第15天后.
结论:
- COVID-19与急症监护室获得的MDRB BSI的风险增加有显著的关联.
- 与COVID-19相关的风险增加从第15天开始变得显著.
- MDRB BSI增加了ICU死亡率,但COVID-19状态并没有显著改变这一关联.
相关概念视频
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
4.3K
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
4.3K
Healthcare Associated Infections II: Preventive Measures
2.7K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.7K
Factors Affecting the Risk of Infection
12.0K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.0K
Endocarditis I: Introduction
12
Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
12
Infection
8.1K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
8.1K
Development of Antibiotic Resistance
41
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
41


