协调阿莫西西林剂量,持续时间和配方,用于儿童急性呼吸道感染
Dhanya Dharmapalan1, Julia Bielicki2, Mike Sharland2
1Consultant in Pediatric Infectious Diseases, Apollo Hospitals, Navi Mumbai 400614, India.
Antibiotics (Basel, Switzerland)
|July 29, 2023
概括
协调儿童呼吸道感染的阿莫西西林剂量至关重要. 世界卫生组织 世界卫生组织
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 儿科指南对常见的呼吸道感染提出了不一致的阿莫西西林剂量建议.
- 缺乏协调使计划交付和抗生素管理变得复杂.
- 影响最佳剂量的因素包括药理动力学,常见的病原体,抗菌素耐药性,成本和易于使用.
研究的目的:
- 倡导针对儿科呼吸道感染进行协调的阿莫西西林剂量和配方.
- 为了使儿科剂量与世界卫生组织 (WHO) EML AWaRe 书籍建议保持一致.
- 评估使用世卫组织推的儿童配方 (可分散片) 的可行性.
主要方法:
- 对当前针对呼吸道感染的儿科阿莫西西林剂量指南的审查.
- 世界卫生组织的分析 EML AWaRe 关于使用抗生素的书籍建议.
- 对阿莫西西林可分散片 (DT) 配方 (250 mg 和 500 mg) 的评估,以实现世卫组织的剂量.
主要成果:
- 世卫组织的AWaRe书建议高剂量的阿莫西西林,每天服用两次,持续5天,用于不复杂的呼吸道感染.
- 世卫组织推的阿莫西西林可分散片 (250毫克和500毫克) 可以有效地为婴儿和老年儿童提供推的剂量方案.
- 目前这些特定的可分散片强度的可用性可能在公共和私人医疗保健部门有限.
结论:
- 按照世卫组织的指导方针,使用250毫克和500毫克可分散片可以实现协调的阿莫西西林剂量.
- 增加世卫组织推的阿莫西西林可分散片的可用性,对于改善儿科护理中获得基本抗生素的机会至关重要.
- 标准化阿莫西西林配方和剂量可以提高治疗疗效,并打击抗菌素耐药性.
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